| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase kinase 6 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 10:46:00 | MAP3K6 should no longer be considered a gastric cancer (GC) predisposition gene, whereas deleterious CTNNA1 variants are confirmed as an infrequent cause of GC susceptibility. Biallelic MYD88 germline mutations are at most a very rare cause of GC susceptibility. | 29330337 |
| 2016-05-07 10:27:00 | Data show that the MAPKKK6 ASK2, a modulator of MAPKKK5 ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing interferon-beta (IFNB) expression. | 26243192 |
| 2015-07-04 15:24:00 | MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for familial gastric cancer | 25340522 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 19913121 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | 20628086 |
| Type | IDs |
|---|---|
| Synonymous | ASK2, MAPKKK6, MEKK6 |
| Gene |
UniProtKB-ID:
M3K6_HUMAN
UniprotKB:
O95382
UniParc:
UPI0001AE7815,
UPI00004702FF,
UPI0000205587
EMBL:
BC129951,
BC129950,
AB208805,
BC015914,
AB167411,
AF100318,
FO393419
Ensembl:
ENSG00000142733
KO:
hsa:9064
|
| Nucleutide sequences |
EMBL-CDS:
BAD12485.1,
AAH15914.1,
BAD92042.1,
AAI29951.1,
AAI29952.1,
AAD05304.1
Ensembl_TRS:
ENST00000374040,
ENST00000357582
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000350195,
ENSP00000363152
RefSeq:
XP_016858260.1,
NP_001284538.1,
NP_004663.3,
XP_016858261.1
|
| Others |
UniRef100:
UniRef100_O95382
UniRef90:
UniRef90_O95382
UniRef50:
UniRef50_O95382
UniGene:
Hs.194694
CCDS:
CCDS72738.1,
CCDS299.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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