| Type | Description |
|---|---|
| Definition | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-07-28 10:46:00 | These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes | 28790117 |
| 2017-09-09 10:05:00 | we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca(2+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. | 27941888 |
| 2016-02-20 11:05:00 | These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity | 25948711 |
| 2015-08-01 10:32:00 | leptin signalling links a novel SFK/ERK1/2-mediated pathway and SK1 expression. | 25482303 |
| 2014-11-08 11:54:00 | SK1 positivity and high expression were significantly associated with cancer and a shorter 5-year and overall survival. | 24587339 |
| Type | IDs |
|---|---|
| Synonymous | ATPSK1, PAPSS, SK1 |
| Gene |
UniProtKB-ID:
PAPS1_HUMAN
UniprotKB:
O43252
UniParc:
UPI0000132102
EMBL:
AF097713,
BC050627,
Y10387,
BC011392,
AF097719,
AF105227,
CR457028,
AF097712,
AF097717,
AF033026,
AF016496,
AF097710,
AF097714,
U53447,
AF097711,
AF097721,
AK292774,
AF097718,
AF097715,
AF097716,
CH471057,
AF097720
Ensembl:
ENSG00000138801
KO:
hsa:9061
|
| Nucleutide sequences |
EMBL-CDS:
CAA71413.1,
AAC39894.1,
CAG33309.1,
BAF85463.1,
AAC28429.1,
EAX06210.1,
AAD09325.1,
AAF40236.1,
AAH11392.1,
AAF40235.1,
AAH50627.1
Ensembl_TRS:
ENST00000265174
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000265174
RefSeq:
XP_011530703.1,
XP_011530702.1,
NP_005434.4
|
| Others |
UniRef100:
UniRef100_O43252
UniRef90:
UniRef90_O43252
UniRef50:
UniRef50_O43252
UniGene:
Hs.368610
CCDS:
CCDS3676.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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