| Type | Description |
|---|---|
| Definition | NFS1 cysteine desulfurase |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 12:23:00 | By different methods, this study identified a MOCS3-independent novel localization of NFS1 at the centrosome. | 30817134 |
| 2019-08-10 11:55:00 | The molecular structure of the human mitochondrial cysteine desulfurase complex consisting of two copies each of NFS1, ISD11, and acyl carrier protein has been described. | 29983374 |
| 2019-06-08 12:54:00 | Study reports 3.2 A resolution cryo-electron microscopy structure of the FXN-bound active human iron-sulfur clusters biosynthesis complex. FXN binds at the interface of two NFS1 and one ISCU subunits, modifying the local environment of a bound zinc ion that would otherwise inhibit NFS1 activity in complexes without FXN. | 31101807 |
| 2018-12-01 11:52:00 | FXN binds the NFS1-ISD11-ACP-ISCU complex (SDAU), to activate the desulfurase activity and Fe-S cluster biosynthesis. In the absence of FXN, the NFS1-ISD11-ACP (SDA) complex was reportedly inhibited by binding of recombinant ISCU | 30031876 |
| 2018-06-09 12:05:00 | analysis of the NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters | 28634302 |
| Type | IDs |
|---|---|
| Synonymous | HUSSY-08, IscS, NIFS |
| Gene |
UniProtKB-ID:
NFS1_HUMAN,
Q53FP3_HUMAN
UniprotKB:
Q9Y697,
Q53FP3
UniParc:
UPI0001E92A34,
UPI000050A90D,
UPI000013D34D,
UPI000046FF48
EMBL:
AL109827,
AK223239,
BC065560,
AF097025,
AK001470,
AK302023,
AL357374,
AJ010952,
CH471077
Ensembl:
ENSG00000244005
KO:
hsa:9054
|
| Nucleutide sequences |
EMBL-CDS:
AAH65560.1,
EAW76170.1,
EAW76172.1,
BAG63421.1,
CAA09424.1,
AAD09187.2,
BAG50917.1,
BAD96959.1
Gene_ORFName:
HUSSY-08
Ensembl_TRS:
ENST00000541387,
ENST00000374085,
ENST00000374092,
ENST00000397425
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363198,
ENSP00000380570,
ENSP00000440897,
ENSP00000363205
RefSeq:
NP_066923.3,
NP_001185918.1
|
| Others |
UniRef100:
UniRef100_Q53FP3,
UniRef100_Q9Y697
UniRef90:
UniRef90_Q9Y697
UniRef50:
UniRef50_Q9Y697
UniGene:
Hs.194692
CCDS:
CCDS13262.1,
CCDS56185.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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