| Type | Description |
|---|---|
| Definition | dual oxidase maturation factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-30 13:03:00 | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. | 33420071 |
| 2019-08-10 12:24:00 | Study shows that DUOXA1 is overexpressed in platinum-resistant ovarian cancer (OC) cells, resulting in over production of reactive oxygen species Elevated level sustains the activation of ATR-Chk1 pathway, leading to resistance to cisplatin in OC cells. Clinical studies also confirm the activation of ATR and DOUXA1 in OC patients, and elevated DOUXA1 or ATR-Chk1 pathway correlates with poor prognosis. | 29704517 |
| 2018-01-13 14:33:00 | We analyzed the expression of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1. | 27262981 |
| 2010-03-29 11:35:00 | DUOXA1 transient overexpression affected the cell-cell adhesion by modulating the actin cytoskeleton | 19322654 |
| 2010-01-21 00:00:00 | Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. | 19339556 |
| Type | IDs |
|---|---|
| Synonymous | NIP, NUMBIP, mol |
| Gene |
UniProtKB-ID:
DOXA1_HUMAN,
B5M0C0_HUMAN,
A8K9Q6_HUMAN,
B5M0B8_HUMAN,
B5M0B7_HUMAN
UniprotKB:
Q1HG43,
B5M0C0,
A8K9Q6,
B5M0B8,
B5M0B7
UniParc:
UPI00017FB1A2,
UPI000006D4D4,
UPI00004088B6,
UPI0000071E2C
EMBL:
AK292771,
EU927394,
CH471082,
EU927395,
DQ489735,
BC029819,
AK056896,
EU927397,
EU927396,
AC091117,
BC020841
Ensembl:
ENSG00000140254
KO:
hsa:90527
|
| Nucleutide sequences |
EMBL-CDS:
BAB71304.1,
ABF48257.1,
AAH20841.1,
AAH29819.1,
ACH57456.1,
BAF85460.1,
ACH57455.1,
EAW77291.1,
ACH57454.1,
EAW77290.1,
EAW77293.1,
EAW77292.1,
ACH57453.1
Gene_ORFName:
hCG_2036886,
hCG_2036886
Ensembl_TRS:
ENST00000558422,
ENST00000267803,
ENST00000558996,
ENST00000559014,
ENST00000560572,
ENST00000613425,
ENST00000430224
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000453569,
ENSP00000454084,
ENSP00000454019,
ENSP00000267803,
ENSP00000453836,
ENSP00000415512,
ENSP00000480154
RefSeq:
XP_006720806.1,
XP_011520485.1,
NP_653166.2,
NP_001263194.1,
XP_011520483.1,
XP_006720808.1,
XP_011520486.1,
NP_001371278.1,
XP_006720814.1,
NP_001263197.1,
XP_006720809.1,
XP_006720810.1,
XP_011520488.1,
XP_006720815.2,
NP_001263193.1,
NP_001263195.1,
XP_006720817.1,
NP_001263196.1,
XP_011520487.1
|
| Others |
UniRef100:
UniRef100_Q1HG43,
UniRef100_B5M0B8,
UniRef100_B5M0C0,
UniRef100_A8K9Q6
UniRef90:
UniRef90_A0A2K5JQG9,
UniRef90_Q1HG43,
UniRef90_G1R1H2
UniRef50:
UniRef50_W5QIS5,
UniRef50_Q1HG43
UniGene:
Hs.356664
CCDS:
CCDS61619.1,
CCDS10119.1,
CCDS61621.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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