| Type | Description |
|---|---|
| Definition | TOPBP1 interacting checkpoint and replication regulator |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 10:25:00 | The conserved C-terminal domain of DUE-B is required for its binding to TopBP1, Treslin, Cdc45, and the MCM2-7 complex, as well as for the efficient loading of Treslin, Cdc45, and TopBP1 on chromatin | 30037903 |
| 2018-04-28 10:14:00 | these data uncover two distinct mechanisms by which mutp53 enhances DNA replication: (i) Both contact and conformational mutp53s can bind TopBP1 and attenuate the checkpoint response to replication stress, and (ii) during normal growth, contact (but not conformational) mutp53s can override the Cdk2 requirement to promote replication by facilitating the TopBP1/Treslin interaction. | 28439015 |
| 2018-02-24 10:33:00 | The extended S phase in Ensa-depleted cells is completely rescued by the overexpression of Treslin. | 28785014 |
| 2017-09-23 14:08:00 | Variation at rs12913965 may affect the risk for shoulder dislocation by affecting the activity of either TICRR or ISG20. | 28521375 |
| 2015-04-25 11:31:00 | phosphorylated TICRR is limiting for S-phase progression | 25737283 |
| Type | IDs |
|---|---|
| Synonymous | C15orf42, SLD3, Treslin |
| Gene |
UniProtKB-ID:
TICRR_HUMAN
UniprotKB:
Q7Z2Z1
UniParc:
UPI0000D61399,
UPI0001D14795
EMBL:
BX538335,
AC013391,
AK074727,
AK315750,
AC013787,
GQ227787,
BC002881,
AK123612,
DR731357,
BC033209
Ensembl:
ENSG00000140534
KO:
hsa:90381
|
| Nucleutide sequences |
EMBL-CDS:
BAC11165.1,
AAH33209.2,
CAD98102.1,
AAH02881.2,
BAG38104.1,
ADC30133.1,
BAG53921.1
Ensembl_TRS:
ENST00000268138,
ENST00000560985
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000268138,
ENSP00000453306
RefSeq:
NP_001294954.1,
NP_689472.3
|
| Others |
UniRef100:
UniRef100_Q7Z2Z1
UniRef90:
UniRef90_Q7Z2Z1
UniRef50:
UniRef50_Q7Z2Z1
UniGene:
Hs.441708
CCDS:
CCDS76791.1,
CCDS10352.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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