| Type | Description |
|---|---|
| Definition | DDB1 and CUL4 associated factor 15 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:42:00 | aryl-sulfonamides neo-functionalize a shallow, non-conserved pocket on DCAF15 to selectively bind and degrade RBM39 and the closely related splicing factor RBM23 without the requirement for a high-affinity ligand | 31686031 |
| 2020-04-25 12:29:00 | structural and mutational analysis of how indisulam mediates the DCAF15-RBM39 interaction | 31819272 |
| 2017-12-23 11:23:00 | DCAF15 expression may be a useful biomarker to guide clinical trials of splicing inhibitor sulfonamides(SPLAMs). | 28302793 |
| Type | IDs |
|---|---|
| Synonymous | C19orf72 |
| Gene |
UniProtKB-ID:
DCA15_HUMAN
UniprotKB:
Q66K64
UniParc:
UPI0000203531
EMBL:
BC013280,
BC080575,
BC002926,
CH471106,
AK093072
Ensembl:
ENSG00000132017,
ENSG00000288453
KO:
hsa:90379
|
| Nucleutide sequences |
EMBL-CDS:
EAW84386.1,
BAG52648.1,
AAH80575.1,
AAH13280.2,
AAH02926.2
Ensembl_TRS:
ENST00000672437,
ENST00000254337
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000500158,
ENSP00000254337
RefSeq:
NP_612362.2
|
| Others |
UniRef100:
UniRef100_Q66K64
UniRef90:
UniRef90_Q66K64
UniRef50:
UniRef50_Q66K64
UniGene:
Hs.443636
CCDS:
CCDS32926.1
|
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31626998 |
J Proteomics Xinglong Jia , Lulu Pan , Mingrui Zhu , Hao Hu , Linhui Zhai , Jie Liu , Min Hu , Bin Liu , Minjia Tan |
2020-01-06 | - |
| 31686031 |
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol Tyler B Faust , Hojong Yoon , RadosÅaw P Nowak , Katherine A Donovan , Zhengnian Li , Quan Cai , Nicholas A Eleuteri , Tinghu Zhang , Nathanael S Gray , Eric S Fischer |
2020-01-01 | - |
| 31819272 |
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat Chem Biol Dirksen E Bussiere , Lili Xie , Honnappa Srinivas , Wei Shu , Ashley Burke , Celine Be , Junping Zhao , Adarsh Godbole , Dan King , Rajeshri G Karki , Viktor Hornak , Fangmin Xu , Jennifer Cobb , Nathalie Carte , Andreas O Frank , Alexandra Frommlet , Patrick Graff , Mark Knapp , Aleem Fazal , Barun Okram , Songchun Jiang , Pierre-Yves Michellys , Rohan Beckwith , Hans Voshol , Christian Wiesmann , Jonathan M Solomon , Joshiawa Paulk |
2020-01-01 | - |
| 31452512 |
Elife Matthew F Pech , Linda E Fong , Jacqueline E Villalta , Leanne Jg Chan , Samir Kharbanda , Jonathon J O'Brien , Fiona E McAllister , Ari J Firestone , Calvin H Jan , Jeffrey Settleman |
2019-08-27 | - |
| 28786561 |
Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. FEBS J. Juline Poirson , Elise Biquand , Marie-Laure Straub , Patricia Cassonnet , Yves Nominé , Louis Jones , Sylvie van der Werf , Gilles Travé , Katia Zanier , Yves Jacob , Caroline Demeret , Murielle Masson |
2017-10-01 | - |
| 28437394 |
Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat. Chem. Biol. Taisuke Uehara , Yukinori Minoshima , Koji Sagane , Naoko Hata Sugi , Kaoru Ogawa Mitsuhashi , Noboru Yamamoto , Hiroshi Kamiyama , Kentaro Takahashi , Yoshihiko Kotake , Mai Uesugi , Akira Yokoi , Atsushi Inoue , Taku Yoshida , Miyuki Mabuchi , Akito Tanaka , Takashi Owa |
2017-06-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28302793 |
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science Ting Han , Maria Goralski , Nicholas Gaskill , Emanuela Capota , Jiwoong Kim , Tabitha C Ting , Yang Xie , Noelle S Williams , Deepak Nijhawan |
2017-04-28 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| 1 |
Institute for Research in Biomedicine (IRB Barcelona) |
1 |
| 2 |
Biogen Inc., 250 Binney Street, Cambridge, Massachusetts 02142, USA. |
1 |
| 3 |
Lunenfeld-Tanenbaum Research Institute (LTRI) |
1 |
| 4 |
Institute for Solid State Physics and Optics |
1 |
| 5 |
McGill University |
1 |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| 1 |
J Wade Harper |
3 |
| 2 |
Joao A Paulo |
2 |
| 3 |
John Szpyt |
2 |
| 4 |
Steven P Gygi |
2 |
| 5 |
Fana Gebreab |
2 |
目前还没有研究热点人员