| Type | Description |
|---|---|
| Definition | polycystin 2 like 1, transient receptor potential cation channel |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:01:00 | Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population. | 33268808 |
| 2020-03-28 10:52:00 | Opening TRPP2 (PKD2L1) requires the transfer of gating charges. | 31315976 |
| 2019-04-20 11:51:00 | Charge-neutralizing mutations (K452Q, K455Q and K461Q) in transmembrane segment 4 reduced gating charges, positively shifted the Boltzmann-type activation curve [i.e., open probability (P open)-V curve] and altered the time-courses of activation/deactivation of PKD2L1, indicating that this region constitutes part of a voltage sensor. | 28852171 |
| 2019-03-30 11:07:00 | The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here the authors show that these differences are reflected in the architecture of polycystin 2-l1. | 30004384 |
| 2019-03-09 12:36:00 | Clustered phosphorylation sites, Ser-682, Ser-685, and Ser-686 are significant for the channel regulation by phosphorylation. | 29230552 |
| Type | IDs |
|---|---|
| Synonymous | PCL, PKD2L, PKDL, TRPP3 |
| Gene |
UniProtKB-ID:
PK2L1_HUMAN,
Q1L4F0_HUMAN
UniprotKB:
Q9P0L9,
Q1L4F0
UniParc:
UPI000002B041,
UPI0003E30FBC,
UPI000002B043,
UPI0000130FED,
UPI000002B042,
UPI0000D63F7B
EMBL:
CH471066,
AF053316,
AF153465,
AF153466,
AF153461,
AF153473,
AF073481,
BC025665,
AF153469,
AF153474,
AL139819,
AF153470,
AF153460,
AF094827,
AF153462,
AF153471,
AF153467,
DQ084244,
AF153463,
AF153472,
AF153459,
AF153464,
AF153468
Ensembl:
ENSG00000107593
KO:
hsa:9033
|
| Nucleutide sequences |
EMBL-CDS:
EAW49833.1,
AAD41638.1,
AAD51859.1,
AAD08695.1,
AAF28108.1,
AAH25665.1,
AAZ31363.1
Ensembl_TRS:
ENST00000318222
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000325296
RefSeq:
NP_001240766.1,
XP_016872365.1,
XP_011538627.1,
NP_057196.2,
XP_016872364.1,
XP_011538625.1
|
| Others |
UniRef100:
UniRef100_Q9P0L9,
UniRef100_Q1L4F0
UniRef90:
UniRef90_A0A2K5EIJ0,
UniRef90_Q9P0L9
UniRef50:
UniRef50_Q9P0L9
UniGene:
Hs.159241
CCDS:
CCDS7492.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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