| Type | Description |
|---|---|
| Definition | cholesterol 25-hydroxylase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:30:00 | we observed that cAMP-dependent transcription factor (ATF3) weakly binds to the CH25H promoter, suggesting cooperation with However, ZIKV-induced CH25H was independent of type I interferon. These findings provide important information for understanding how the Zika virus induces innate inflammatory responses and promotes the expression of anti-viral CH25H protein. | 31375561 |
| 2019-11-30 10:18:00 | Overexpression of both human and murine CH25H inhibited rabies virus (RABV) infection in HEK-293T cells. | 31552533 |
| 2019-10-19 12:33:00 | Limited analysis of leukocytes from melanoma patients is suggestive of an association between the loss of CH25H and poor disease outcome. CH25H acts to restrict tumor-derived extracellular vesicles uptake and limit the education of healthy cells to promote metastases. | 30645975 |
| 2019-09-14 11:02:00 | The CH25H rs13500 polymorphism is associated with an increased Alzheimer's disease (AD) risk in the Turkish population and co-occurrence of CH25H 'T' and APOE epsilon4 alleles is a strong risk factor for AD. Based on our overall results, it can be concluded that CH25H might have a role in the pathogenesis of AD together with, and independently from APOE | 30684189 |
| 2018-09-15 10:48:00 | We examined whether 25HC restricts infection by mammalian reovirus. Results suggest that 25HC inhibits the efficiency of cellular entry of reovirus virions, which may require specific endosomal membrane dynamics for efficient membrane penetration. | 29950420 |
| Type | IDs |
|---|---|
| Synonymous | C25H |
| Gene |
UniProtKB-ID:
CH25H_HUMAN
UniprotKB:
O95992
UniParc:
UPI0000073DCF
EMBL:
AF059214,
BC072430,
CH471066,
AL513533,
BC017843,
AF059212,
AK314865
Ensembl:
ENSG00000138135
KO:
hsa:9023
|
| Nucleutide sequences |
EMBL-CDS:
AAH17843.1,
BAG37380.1,
AAC97483.1,
EAW50146.1,
AAC97481.1,
AAH72430.1
Ensembl_TRS:
ENST00000371852
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360918
RefSeq:
NP_003947.1
|
| Others |
UniRef100:
UniRef100_O95992
UniRef90:
UniRef90_O95992
UniRef50:
UniRef50_O95992
UniGene:
Hs.47357
CCDS:
CCDS7400.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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