| Type | Description |
|---|---|
| Definition | TNF superfamily member 18 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:25:00 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. | 33654081 |
| 2020-01-11 10:58:00 | our studies have demonstrated a critical role of GITRL in modulating the suppressive function of myeloid-derived suppressor cells | 30760623 |
| 2018-06-02 11:43:00 | Cultured HCN-2 neurons were incubated at different times with GITRL and/or TRAIL, and thereafter nucleic acid and protein expression were measured. HCN-2 cells do not express GITRL mRNA, but the latter is induced after treatment with TRAIL. Cells did not express the GITRL receptor GITR mRNA, neither in control cultures, nor after treatment with TRAIL. TRAIL, when associated to GITRL, exerted additive toxic effects. | 28524007 |
| 2017-02-25 11:46:00 | GITRL levels are significantly elevated in rheumatoid arthritis serum and synovial fluid and are positively correlated with autoantibody production in rheumatoid arthritis, suggesting a role of GITRL in the development of rheumatoid arthritis. | 27098050 |
| 2017-01-14 11:11:00 | GITRL modulates the activities of p38 MAPK and to promote Th17 cell differentiation in autoimmune arthritis. | 26657118 |
| Type | IDs |
|---|---|
| Synonymous | AITRL, GITRL, TL6, TNLG2A, hGITRL |
| Gene |
UniProtKB-ID:
TNF18_HUMAN,
A0A0U5JXL4_HUMAN
UniprotKB:
Q9UNG2,
A0A0U5JXL4
UniParc:
UPI000153D776
EMBL:
AF117713,
AY358868,
BC093986,
LN874318,
CH471067,
AK313273,
AL031599,
BC069319,
AF125303,
BC112032,
BC069111
Ensembl:
ENSG00000120337
KO:
hsa:8995
|
| Nucleutide sequences |
EMBL-CDS:
BAG36082.1,
AAD19695.1,
EAW90937.1,
AAH69319.1,
AAH69111.1,
AAH93986.1,
AAI12033.1,
AAD22634.1,
AAQ89227.1,
CTQ86083.1
Gene_ORFName:
UNQ149/PRO175
Ensembl_TRS:
ENST00000404377
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385470
RefSeq:
NP_005083.3
|
| Others |
UniRef100:
UniRef100_Q9UNG2
UniRef90:
UniRef90_Q9UNG2
UniRef50:
UniRef50_Q9UNG2
UniGene:
Hs.248197
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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