| Type | Description |
|---|---|
| Definition | ubiquitin protein ligase E3B |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:34:00 | TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation. | 33298911 |
| 2018-06-23 10:49:00 | we present four patients with five novel UBE3B mutations and propose the inclusion of clinical features to the characteristics of Kaufman oculocerebrofacial syndrome, including prominence of the cheeks and limb anomalies. | 29160006 |
| 2017-07-08 12:29:00 | studies demonstrate that UBE3B is an E3 ubiquitin ligase and reveal that the enzyme is regulated by calmodulin. Furthermore, the modulation of UBE3B via calmodulin and calcium implicates a role for calcium signaling in mitochondrial protein ubiquitylation, protein turnover, and disease | 28003368 |
| 2017-06-24 10:54:00 | Sanger sequencing was negative for the DOORS syndrome gene TBC1D24 but exome sequencing identified a homozygous deletion in UBE3B (NM_183415:c.3139_3141del, p.1047_1047del) located within the terminal portion of the HECT domain | 28003643 |
| 2017-04-19 16:07:00 | The E3 ligase activity of UBE3B is regulated by its interaction with calmodulin via the N-terminal IQ domain. | 28003368 |
| Type | IDs |
|---|---|
| Synonymous | BPIDS, KOS |
| Gene |
UniProtKB-ID:
UBE3B_HUMAN,
A0A024RBI2_HUMAN
UniprotKB:
Q7Z3V4,
A0A024RBI2
UniParc:
UPI000013D710,
UPI000013DC3B,
UPI000019AB5C
EMBL:
AL096740,
BC141880,
BC032301,
BC108705,
BC051266,
BX537403,
CH471054,
AC007570,
AF251046,
BC068221
Ensembl:
ENSG00000151148
KO:
hsa:89910
|
| Nucleutide sequences |
EMBL-CDS:
AAI08706.1,
AAH68221.1,
AAI41881.1,
AAH51266.1,
AAH32301.1,
CAH56410.1,
CAD97645.1,
AAK28419.2,
EAW97865.1,
EAW97866.1
Gene_ORFName:
hCG_40331
Ensembl_TRS:
ENST00000449510,
ENST00000342494,
ENST00000540230,
ENST00000434735,
ENST00000536398,
ENST00000340074
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440585,
ENSP00000443565,
ENSP00000391529,
ENSP00000340596,
ENSP00000395802,
ENSP00000342614
RefSeq:
NP_569733.2,
NP_001257378.1,
XP_011537261.1,
NP_001257380.1,
XP_016875684.1,
XP_016875685.1,
XP_011537263.1,
XP_005254044.1,
XP_006719745.1,
NP_001257379.1,
XP_006719744.1,
XP_024305037.1,
NP_904324.1
|
| Others |
UniRef100:
UniRef100_Q7Z3V4
UniRef90:
UniRef90_Q7Z3V4
UniRef50:
UniRef50_Q7Z3V4
UniGene:
Hs.374067
CCDS:
CCDS58277.1,
CCDS9129.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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