| Type | Description |
|---|---|
| Definition | potassium two pore domain channel subfamily K member 17 |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 12:17:00 | 2 novel gene variants in REM2 and KCNK17 that provide a physiologically plausible explanation for variable expressivity in a large subset of patients in a multigenerational long QT syndrome type 2 family | 29431731 |
| 2017-10-21 12:34:00 | The results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli. | 29016681 |
| 2015-06-06 10:09:00 | The T carrier of an single-nucleotide polymorphism is associated with reduced risk of cerebral hemorrhage in the Chinese population. | 25179130 |
| 2015-02-14 10:10:00 | This study demonstrates that Gly88 is a crucial residue for normal TASK-4 gating behavior and that the channel is strongly expressed in the cardiac conduction system. | 24972929 |
| 2013-08-03 12:02:00 | The rs10947803 SNP (A allele) in KCNK17 increases the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population. | 23391755 |
| Type | IDs |
|---|---|
| Synonymous | K2p17.1, TALK-2, TALK2, TASK-4, TASK4 |
| Gene |
UniProtKB-ID:
KCNKH_HUMAN
UniprotKB:
Q96T54
UniParc:
UPI0000D4E02B,
UPI0000127A59
EMBL:
BC025726,
AF358910,
AL136087,
AF339912,
AY358853
Ensembl:
ENSG00000124780
KO:
hsa:89822
|
| Nucleutide sequences |
EMBL-CDS:
AAK49533.1,
AAK28551.1,
AAH25726.1,
AAQ89212.1
Gene_ORFName:
UNQ5816/PRO19634
Ensembl_TRS:
ENST00000453413,
ENST00000373231
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000401271,
ENSP00000362328
RefSeq:
NP_001128583.1,
NP_113648.2
|
| Others |
UniRef100:
UniRef100_Q96T54
UniRef90:
UniRef90_Q96T54
UniRef50:
UniRef50_Q96T54
UniGene:
Hs.162282
CCDS:
CCDS4842.1,
CCDS47419.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 29431731 |
Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity. J. Clin. Invest. Sam Chai , Xiaoping Wan , Angelina Ramirez-Navarro , Paul J Tesar , Elizabeth S Kaufman , Eckhard Ficker , Alfred L George , Isabelle Deschênes |
2018-03-01 | - |
| 29016681 |
PLoS ONE Yoshiaki Suzuki , Kanako Tsutsumi , Tatsuya Miyamoto , Hisao Yamamura , Yuji Imaizumi |
2017-01-01 | - |
| 25179130 |
J Stroke Cerebrovasc Dis Lingbin He , Qingfeng Ma , Yongqin Wang , Xin Liu , Yuan Yuan , Yongzhi Zhang , Wenjing Ou , Lisheng Liu , Xuerui Tan , Xingyu Wang |
2014-10-01 |
KCNK17
|
| 24972929 |
Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder. EMBO Mol Med Corinna Friedrich , Susanne Rinné , Sven Zumhagen , Aytug K Kiper , Nicole Silbernagel , Michael F Netter , Birgit Stallmeyer , Eric Schulze-Bahr , Niels Decher |
2014-07-01 | - |
| 24509480 |
Nat. Genet. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium , Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium , South Asian Type 2 Diabetes (SAT2D) Consortium , Mexican American Type 2 Diabetes (MAT2D) Consortium , Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium , Anubha Mahajan , Min Jin Go , Weihua Zhang , Jennifer E Below , Kyle J Gaulton , Teresa Ferreira , Momoko Horikoshi , Andrew D Johnson , Maggie C Y Ng , Inga Prokopenko , Danish Saleheen , Xu Wang , Eleftheria Zeggini , Goncalo R Abecasis , Linda S Adair , Peter Almgren , Mustafa Atalay , Tin Aung , Damiano Baldassarre , Beverley Balkau , Yuqian Bao , Anthony H Barnett , Ines Barroso , Abdul Basit , Latonya F Been , John Beilby , Graeme I Bell , Rafn Benediktsson , Richard N Bergman , Bernhard O Boehm , Eric Boerwinkle , Lori L Bonnycastle , Noël Burtt , Qiuyin Cai , Harry Campbell , Jason Carey , Stephane Cauchi , Mark Caulfield , Juliana C N Chan , Li-Ching Chang , Tien-Jyun Chang , Yi-Cheng Chang , Guillaume Charpentier , Chien-Hsiun Chen , Han Chen , Yuan-Tsong Chen , Kee-Seng Chia , Manickam Chidambaram , Peter S Chines , Nam H Cho , Young Min Cho , Lee-Ming Chuang , Francis S Collins , Marylin C Cornelis , David J Couper , Andrew T Crenshaw , Rob M van Dam , John Danesh , Debashish Das , Ulf de Faire , George Dedoussis , Panos Deloukas , Antigone S Dimas , Christian Dina , Alex S Doney , Peter J Donnelly , Mozhgan Dorkhan , Cornelia van Duijn , Josée Dupuis , Sarah Edkins , Paul Elliott , Valur Emilsson , Raimund Erbel , Johan G Eriksson , Jorge Escobedo , Tonu Esko , Elodie Eury , Jose C Florez , Pierre Fontanillas , Nita G Forouhi , Tom Forsen , Caroline Fox , Ross M Fraser , Timothy M Frayling , Philippe Froguel , Philippe Frossard , Yutang Gao , Karl Gertow , Christian Gieger , Bruna Gigante , Harald Grallert , George B Grant , Leif C Grrop , Chrisropher J Groves , Elin Grundberg , Candace Guiducci , Anders Hamsten , Bok-Ghee Han , Kazuo Hara , Neelam Hassanali , Andrew T Hattersley , Caroline Hayward , Asa K Hedman , Christian Herder , Albert Hofman , Oddgeir L Holmen , Kees Hovingh , Astradur B Hreidarsson , Cheng Hu , Frank B Hu , Jennie Hui , Steve E Humphries , Sarah E Hunt , David J Hunter , Kristian Hveem , Zafar I Hydrie , Hiroshi Ikegami , Thomas Illig , Erik Ingelsson , Muhammed Islam , Bo Isomaa , Anne U Jackson , Tazeen Jafar , Alan James , Weiping Jia , Karl-Heinz Jöckel , Anna Jonsson , Jeremy B M Jowett , Takashi Kadowaki , Hyun Min Kang , Stavroula Kanoni , Wen Hong L Kao , Sekar Kathiresan , Norihiro Kato , Prasad Katulanda , Kirkka M Keinanen-Kiukaanniemi , Ann M Kelly , Hassan Khan , Kay-Tee Khaw , Chiea-Chuen Khor , Hyung-Lae Kim , Sangsoo Kim , Young Jin Kim , Leena Kinnunen , Norman Klopp , Augustine Kong , Eeva Korpi-Hyövälti , Sudhir Kowlessur , Peter Kraft , Jasmina Kravic , Malene M Kristensen , S Krithika , Ashish Kumar , Jesus Kumate , Johanna Kuusisto , Soo Heon Kwak , Markku Laakso , Vasiliki Lagou , Timo A Lakka , Claudia Langenberg , Cordelia Langford , Robert Lawrence , Karin Leander , Jen-Mai Lee , Nanette R Lee , Man Li , Xinzhong Li , Yun Li , Junbin Liang , Samuel Liju , Wei-Yen Lim , Lars Lind , Cecilia M Lindgren , Eero Lindholm , Ching-Ti Liu , Jian Jun Liu , Stéphane Lobbens , Jirong Long , Ruth J F Loos , Wei Lu , Jian'an Luan , Valeriya Lyssenko , Ronald C W Ma , Shiro Maeda , Reedik Mägi , Satu Männisto , David R Matthews , James B Meigs , Olle Melander , Andres Metspalu , Julia Meyer , Ghazala Mirza , Evelin Mihailov , Susanne Moebus , Viswanathan Mohan , Karen L Mohlke , Andrew D Morris , Thomas W Mühleisen , Martina Müller-Nurasyid , Bill Musk , Jiro Nakamura , Eitaro Nakashima , Pau Navarro , Peng-Keat Ng , Alexandra C Nica , Peter M Nilsson , Inger Njølstad , Markus M Nöthen , Keizo Ohnaka , Twee Hee Ong , Katharine R Owen , Colin N A Palmer , James S Pankow , Kyong Soo Park , Melissa Parkin , Sonali Pechlivanis , Nancy L Pedersen , Leena Peltonen , John R B Perry , Annette Peters , Janini M Pinidiyapathirage , Carl G Platou , Simon Potter , Jackie F Price , Lu Qi , Venkatesan Radha , Loukianos Rallidis , Asif Rasheed , Wolfgang Rathman , Rainer Rauramaa , Soumya Raychaudhuri , N William Rayner , Simon D Rees , Emil Rehnberg , Samuli Ripatti , Neil Robertson , Michael Roden , Elizabeth J Rossin , Igor Rudan , Denis Rybin , Timo E Saaristo , Veikko Salomaa , Juha Saltevo , Maria Samuel , Dharambir K Sanghera , Jouko Saramies , James Scott , Laura J Scott , Robert A Scott , Ayellet V Segrè , Joban Sehmi , Bengt Sennblad , Nabi Shah , Sonia Shah , A Samad Shera , Xiao Ou Shu , Alan R Shuldiner , Gunnar SigurÄsson , Eric Sijbrands , Angela Silveira , Xueling Sim , Suthesh Sivapalaratnam , Kerrin S Small , Wing Yee So , Alena StanÄáková , Kari Stefansson , Gerald Steinbach , Valgerdur Steinthorsdottir , Kathleen Stirrups , Rona J Strawbridge , Heather M Stringham , Qi Sun , Chen Suo , Ann-Christine Syvänen , Ryoichi Takayanagi , Fumihiko Takeuchi , Wan Ting Tay , Tanya M Teslovich , Barbara Thorand , Gudmar Thorleifsson , Unnur Thorsteinsdottir , Emmi Tikkanen , Joseph Trakalo , Elena Tremoli , Mieke D Trip , Fuu Jen Tsai , Tiinamaija Tuomi , Jaakko Tuomilehto , Andre G Uitterlinden , Adan Valladares-Salgado , Sailaja Vedantam , Fabrizio Veglia , Benjamin F Voight , Congrong Wang , Nicholas J Wareham , Roman Wennauer , Ananda R Wickremasinghe , Tom Wilsgaard , James F Wilson , Steven Wiltshire , Wendy Winckler , Tien Yin Wong , Andrew R Wood , Jer-Yuarn Wu , Ying Wu , Ken Yamamoto , Toshimasa Yamauchi , Mingyu Yang , Loic Yengo , Mitsuhiro Yokota , Robin Young , Delilah Zabaneh , Fan Zhang , Rong Zhang , Wei Zheng , Paul Z Zimmet , David Altshuler , Donald W Bowden , Yoon Shin Cho , Nancy J Cox , Miguel Cruz , Craig L Hanis , Jaspal Kooner , Jong-Young Lee , Mark Seielstad , Yik Ying Teo , Michael Boehnke , Esteban J Parra , Jonh C Chambers , E Shyong Tai , Mark I McCarthy , Andrew P Morris |
2014-03-01 | - |
| 24097068 |
Discovery and refinement of loci associated with lipid levels. Nat. Genet. Cristen J Willer , Ellen M Schmidt , Sebanti Sengupta , Gina M Peloso , Stefan Gustafsson , Stavroula Kanoni , Andrea Ganna , Jin Chen , Martin L Buchkovich , Samia Mora , Jacques S Beckmann , Jennifer L Bragg-Gresham , Hsing-Yi Chang , AyÅe Demirkan , Heleen M Den Hertog , Ron Do , Louise A Donnelly , Georg B Ehret , Tõnu Esko , Mary F Feitosa , Teresa Ferreira , Krista Fischer , Pierre Fontanillas , Ross M Fraser , Daniel F Freitag , Deepti Gurdasani , Kauko Heikkilä , Elina Hyppönen , Aaron Isaacs , Anne U Jackson , à sa Johansson , Toby Johnson , Marika Kaakinen , Johannes Kettunen , Marcus E Kleber , Xiaohui Li , Jian'an Luan , Leo-Pekka Lyytikäinen , Patrik K E Magnusson , Massimo Mangino , Evelin Mihailov , May E Montasser , Martina Müller-Nurasyid , Ilja M Nolte , Jeffrey R O'Connell , Cameron D Palmer , Markus Perola , Ann-Kristin Petersen , Serena Sanna , Richa Saxena , Susan K Service , Sonia Shah , Dmitry Shungin , Carlo Sidore , Ci Song , Rona J Strawbridge , Ida Surakka , Toshiko Tanaka , Tanya M Teslovich , Gudmar Thorleifsson , Evita G Van den Herik , Benjamin F Voight , Kelly A Volcik , Lindsay L Waite , Andrew Wong , Ying Wu , Weihua Zhang , Devin Absher , Gershim Asiki , Inês Barroso , Latonya F Been , Jennifer L Bolton , Lori L Bonnycastle , Paolo Brambilla , Mary S Burnett , Giancarlo Cesana , Maria Dimitriou , Alex S F Doney , Angela Döring , Paul Elliott , Stephen E Epstein , Gudmundur Ingi Eyjolfsson , Bruna Gigante , Mark O Goodarzi , Harald Grallert , Martha L Gravito , Christopher J Groves , Göran Hallmans , Anna-Liisa Hartikainen , Caroline Hayward , Dena Hernandez , Andrew A Hicks , Hilma Holm , Yi-Jen Hung , Thomas Illig , Michelle R Jones , Pontiano Kaleebu , John J P Kastelein , Kay-Tee Khaw , Eric Kim , Norman Klopp , Pirjo Komulainen , Meena Kumari , Claudia Langenberg , Terho Lehtimäki , Shih-Yi Lin , Jaana Lindström , Ruth J F Loos , François Mach , Wendy L McArdle , Christa Meisinger , Braxton D Mitchell , Gabrielle Müller , Ramaiah Nagaraja , Narisu Narisu , Tuomo V M Nieminen , Rebecca N Nsubuga , Isleifur Olafsson , Ken K Ong , Aarno Palotie , Theodore Papamarkou , Cristina Pomilla , Anneli Pouta , Daniel J Rader , Muredach P Reilly , Paul M Ridker , Fernando Rivadeneira , Igor Rudan , Aimo Ruokonen , Nilesh Samani , Hubert Scharnagl , Janet Seeley , Kaisa Silander , Alena StanÄáková , Kathleen Stirrups , Amy J Swift , Laurence Tiret , Andre G Uitterlinden , L Joost van Pelt , Sailaja Vedantam , Nicholas Wainwright , Cisca Wijmenga , Sarah H Wild , Gonneke Willemsen , Tom Wilsgaard , James F Wilson , Elizabeth H Young , Jing Hua Zhao , Linda S Adair , Dominique Arveiler , Themistocles L Assimes , Stefania Bandinelli , Franklyn Bennett , Murielle Bochud , Bernhard O Boehm , Dorret I Boomsma , Ingrid B Borecki , Stefan R Bornstein , Pascal Bovet , Michel Burnier , Harry Campbell , Aravinda Chakravarti , John C Chambers , Yii-Der Ida Chen , Francis S Collins , Richard S Cooper , John Danesh , George Dedoussis , Ulf de Faire , Alan B Feranil , Jean Ferrières , Luigi Ferrucci , Nelson B Freimer , Christian Gieger , Leif C Groop , Vilmundur Gudnason , Ulf Gyllensten , Anders Hamsten , Tamara B Harris , Aroon Hingorani , Joel N Hirschhorn , Albert Hofman , G Kees Hovingh , Chao Agnes Hsiung , Steve E Humphries , Steven C Hunt , Kristian Hveem , Carlos Iribarren , Marjo-Riitta Järvelin , Antti Jula , Mika Kähönen , Jaakko Kaprio , Antero Kesäniemi , Mika Kivimaki , Jaspal S Kooner , Peter J Koudstaal , Ronald M Krauss , Diana Kuh , Johanna Kuusisto , Kirsten O Kyvik , Markku Laakso , Timo A Lakka , Lars Lind , Cecilia M Lindgren , Nicholas G Martin , Winfried März , Mark I McCarthy , Colin A McKenzie , Pierre Meneton , Andres Metspalu , Leena Moilanen , Andrew D Morris , Patricia B Munroe , Inger Njølstad , Nancy L Pedersen , Chris Power , Peter P Pramstaller , Jackie F Price , Bruce M Psaty , Thomas Quertermous , Rainer Rauramaa , Danish Saleheen , Veikko Salomaa , Dharambir K Sanghera , Jouko Saramies , Peter E H Schwarz , Wayne H-H Sheu , Alan R Shuldiner , Agneta Siegbahn , Tim D Spector , Kari Stefansson , David P Strachan , Bamidele O Tayo , Elena Tremoli , Jaakko Tuomilehto , Matti Uusitupa , Cornelia M van Duijn , Peter Vollenweider , Lars Wallentin , Nicholas J Wareham , John B Whitfield , Bruce H R Wolffenbuttel , Jose M Ordovas , Eric Boerwinkle , Colin N A Palmer , Unnur Thorsteinsdottir , Daniel I Chasman , Jerome I Rotter , Paul W Franks , Samuli Ripatti , L Adrienne Cupples , Manjinder S Sandhu , Stephen S Rich , Michael Boehnke , Panos Deloukas , Sekar Kathiresan , Karen L Mohlke , Erik Ingelsson , Gonçalo R Abecasis , Global Lipids Genetics Consortium |
2013-11-01 | - |
| 23391755 |
Neurosci. Lett. Qingfeng Ma , Yongqin Wang , Yue Shen , Xin Liu , Xiaotong Zhu , Hongye Zhang , Lisheng Liu , Xuerui Tan , Lefeng Wang , Xingyu Wang |
2013-02-28 |
KCNK17
|
| 22158537 |
Nat. Genet. Yoon Shin Cho , Chien-Hsiun Chen , Cheng Hu , Jirong Long , Rick Twee Hee Ong , Xueling Sim , Fumihiko Takeuchi , Ying Wu , Min Jin Go , Toshimasa Yamauchi , Yi-Cheng Chang , Soo Heon Kwak , Ronald C W Ma , Ken Yamamoto , Linda S Adair , Tin Aung , Qiuyin Cai , Li-Ching Chang , Yuan-Tsong Chen , Yutang Gao , Frank B Hu , Hyung-Lae Kim , Sangsoo Kim , Young Jin Kim , Jeannette Jen-Mai Lee , Nanette R Lee , Yun Li , Jian Jun Liu , Wei Lu , Jiro Nakamura , Eitaro Nakashima , Daniel Peng-Keat Ng , Wan Ting Tay , Fuu-Jen Tsai , Tien Yin Wong , Mitsuhiro Yokota , Wei Zheng , Rong Zhang , Congrong Wang , Wing Yee So , Keizo Ohnaka , Hiroshi Ikegami , Kazuo Hara , Young Min Cho , Nam H Cho , Tien-Jyun Chang , Yuqian Bao , Ã sa K Hedman , Andrew P Morris , Mark I McCarthy , DIAGRAM Consortium , MuTHER Consortium , Ryoichi Takayanagi , Kyong Soo Park , Weiping Jia , Lee-Ming Chuang , Juliana C N Chan , Shiro Maeda , Takashi Kadowaki , Jong-Young Lee , Jer-Yuarn Wu , Yik Ying Teo , E Shyong Tai , Xiao Ou Shu , Karen L Mohlke , Norihiro Kato , Bok-Ghee Han , Mark Seielstad |
2011-12-11 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21103663 |
Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. Thromb. Haemost. Anne Schaafhausen , Simone Rost , Johannes Oldenburg , Clemens R Müller |
2011-02-01 |
HDAC6,
TMEM35B,
PDIA6,
BCAP31,
ATP6AP2,
IFITM3,
PROCR,
ARL6IP5,
EBP,
YIF1A,
TREX1,
TMEM45B,
CNN3,
COMT,
SLC31A2,
CCDC12,
CXADR,
CCDC167,
VKORC1L1,
SPTSSA,
METTL7B,
AHSG,
ZCCHC24,
FGG,
FGL1,
TRAM1,
FTL,
TMEM256,
GJB1,
PPA2,
SERP1,
TMEM230,
HP,
HPR,
APLP2,
APOA1,
APOA2,
APOC1,
APOC3,
APOC4,
ASGR1,
ASGR2,
MT1X,
PCDH1,
FIS1,
PCMT1,
RMDN1,
SLC15A3,
HSD17B7,
TMBIM4,
MSRB1,
ATP5G3,
SERPINA1,
PIGH,
PLP2,
PPIB,
TMEM176A,
ECHDC1,
HAMP,
SAA1,
SAT1,
MSMO1,
RMND5A,
SLC25A1,
SNORA12,
STAT6,
SURF4,
TF,
C1S,
TMEM242,
VKORC1,
REEP5,
TMEM134,
TMEM120A,
JAGN1,
DPM2,
KCNK17,
CLDN10,
VAPB,
CD9,
HOMER2,
CD63,
CD81
|
| 排名 | 科研单位 | 文献 |
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| 排名 | 研究人员 | 文献 |
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