| Type | Description |
|---|---|
| Definition | TEK receptor tyrosine kinase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:45:00 | Results demonstrated that thrombin promotes pericyte coverage on microvessels following ICH by enhancing activation of Tie2, in which the downstream PI3K/Akt signaling pathway might be involved. | 30527680 |
| 2017-08-19 11:40:00 | These findings suggested that miR-150 could regulate claudin-5 expression and endothelial cell survival by targeting Tie-2, thus affecting the permeability of BBB after permanent middle cerebral artery occlusion in rats, and that miR-150 might be a potential alternative target for the treatment of stroke. | 26887441 |
| 2017-07-22 12:25:00 | Hypoxia significantly increased protein levels of VEGF, KDR, Angiopoiein 1, and Tie2, which were reduced following Compound 49b treatment. These data strongly suggested that Compound 49b protected the retina against I/R-induced injury. This provides additional support for a role of beta-adrenergic receptor actions in the retina. | 27439004 |
| 2017-02-18 10:15:00 | Tie2 extracellular domain initially inhibited angiogenesis, and its degradation relieved inhibition of new vessel formation | 26666854 |
| 2015-02-14 13:15:00 | COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways | 25446117 |
| Type | IDs |
|---|---|
| Synonymous | Tie-2, Tie2 |
| Gene |
UniProtKB-ID:
D3ZCD0_RAT
UniprotKB:
D3ZCD0
UniParc:
UPI0000DA27F7
EMBL:
CH473998,
AC133043,
AABR07049286,
AABR07049285,
AABR07073130
Ensembl:
ENSRNOG00000008587
KO:
rno:89804
|
| Nucleutide sequences |
EMBL-CDS:
EDL97760.1
Gene_ORFName:
rCG_53516
Ensembl_TRS:
ENSRNOT00000032248
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000036086
RefSeq:
NP_001099207.1,
XP_008762132.1
|
| Others |
UniRef100:
UniRef100_D3ZCD0
UniRef90:
UniRef90_Q02858
UniRef50:
UniRef50_Q02763-2
UniGene:
Rn.9159
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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