| Type | Description |
|---|---|
| Definition | sialic acid binding Ig like lectin 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:57:00 | Siglec-10 expression is up-regulated in activated human CD4(+) T cells. | 32046870 |
| 2020-03-21 10:06:00 | Genetic ablation of either CD24 or Siglec-10, as well as blockade of the CD24-Siglec-10 interaction using monoclonal antibodies, robustly augment the phagocytosis of all CD24-expressing human tumours that we tested. Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time. | 31367043 |
| 2018-09-22 10:37:00 | soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. | 29997173 |
| 2015-05-02 12:28:00 | Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC). | 25450598 |
| 2010-04-07 21:39:00 | Observational study of gene-disease association. (HuGE Navigator) | 20237496 |
| Type | IDs |
|---|---|
| Synonymous | PRO940, SIGLEC-10, SLG2 |
| Gene |
UniProtKB-ID:
SIG10_HUMAN,
B7ZL06_HUMAN,
E9PL79_HUMAN
UniprotKB:
Q96LC7,
B7ZL06,
E9PL79
UniParc:
UPI000015909D,
UPI0000047E1A,
UPI000002B3BA,
UPI0000169D78,
UPI0001F77EFF,
UPI0001AE6485,
UPI0000E825CC,
UPI000040C4AE,
UPI0000047E0E,
UPI0001C2BF9A,
UPI000002B3B8
EMBL:
AK289900,
AY029277,
BC009955,
AF311905,
BC143500,
AY032685,
AC008750,
AK303514,
AK290542,
BC101725,
AF310233,
AY358337
Ensembl:
ENSG00000142512
KO:
hsa:89790
|
| Nucleutide sequences |
EMBL-CDS:
AAK55139.1,
AAQ88703.1,
AAH09955.2,
AAK92542.1,
AAK40256.1,
BAF83231.1,
AAK51124.1,
BAF82589.1,
AAK40255.1,
AAI01726.1,
AAI43501.1
Gene_ORFName:
UNQ477/PRO940
Ensembl_TRS:
ENST00000439889,
ENST00000436984,
ENST00000339313,
ENST00000441969,
ENST00000442846,
ENST00000353836,
ENST00000525998
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000395475,
ENSP00000345243,
ENSP00000389132,
ENSP00000408387,
ENSP00000414324,
ENSP00000342389,
ENSP00000431444
RefSeq:
NP_001164632.1,
NP_149121.2,
NP_001309034.1,
NP_001164627.1,
XP_005259423.1,
NP_001164628.1,
NP_001164630.1,
NP_001164629.1,
XP_005259424.1
|
| Others |
UniRef100:
UniRef100_E9PL79,
UniRef100_Q96LC7,
UniRef100_B7ZL06
UniRef90:
UniRef90_E9PL79,
UniRef90_Q96LC7-3,
UniRef90_Q96LC7
UniRef50:
UniRef50_H2QGX2,
UniRef50_Q96LC7
UniGene:
Hs.284813
CCDS:
CCDS54303.1,
CCDS54302.1,
CCDS54305.1,
CCDS54304.1,
CCDS12832.1,
CCDS54301.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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