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8941 CDK5R2

8941

CDK5R2

cyclin dependent kinase 5 regulatory subunit 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition cyclin dependent kinase 5 regulatory subunit 2

研究结论

Date Results Publications
2019-04-20 11:02:00 a biomarker consisting of the phosphorylation of the retinoblastoma protein (Rb) on serine 249 combined with elevated p39 expression. This biomarker correlates with epithelial-to-mesenchymal transition traits in non-small cell lung carcinoma (NSCLC) cells. 30452490
2015-02-21 11:03:00 p39 is essential for recruiting scaffolding protein muskelin to stress fibers. 25128817
2014-01-25 11:10:00 Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. 24085300
2012-08-25 10:21:00 Hepatocellular carcinoma patients with lower p39 expression had poorer overall survival rate than that with high expression. 20936377
2010-07-26 11:50:00 both proteasomal degradation and calpain cleavage of p35 and p39 are stimulated by membrane association, which is in turn mediated via myristoylation of their p10 regions. 20518484

名称对应

Type IDs
Synonymous NCK5AI, P39, p39nck5ai
Gene
UniProtKB-ID: CD5R2_HUMAN
UniprotKB: Q13319
UniParc: UPI000012738F
EMBL: U34051, DQ307839, AC097468
Ensembl: ENSG00000171450
KO: hsa:8941
Nucleutide sequences
EMBL-CDS: AAC50278.1, AAX88916.1, ABB96255.1
Ensembl_TRS: ENST00000302625
Protein sequencees
Ensembl_PRO: ENSP00000304250
RefSeq: NP_003927.1
Others
UniRef100: UniRef100_Q13319
UniRef90: UniRef90_O35926
UniRef50: UniRef50_O35926
UniGene: Hs.158460
CCDS: CCDS2427.1

全选

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研究热度

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