| Type | Description |
|---|---|
| Definition | methyl-CpG binding domain 4, DNA glycosylase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:18:00 | MBD4 is sumoylated in vivo in a DNA damage-specific manner | 31476572 |
| 2019-08-10 11:37:00 | These findings suggest that RNF144A is epigenetically silenced in breast cancer cells by promoter hypermethylation and MBD4. | 29473320 |
| 2019-07-27 12:14:00 | Germ line MBD4 deficiency stimulates clonal hematopoiesis and guides the development of leukemia via recurrent mutations in DNMT3A. | 30049810 |
| 2018-06-02 11:14:00 | Results demonstrated that MBD4 was downregulated, which lead to the overexpression and promoter hypomethylation of CD70 in CD4+ T cells from patients from systemic lupus erythematosus (SLE). This study preliminarily revealed the role and mechanism of MBD4 in the pathogenesis of SLE. | 29018507 |
| 2017-08-19 11:26:00 | a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner | 28542810 |
| Type | IDs |
|---|---|
| Synonymous | MED1 |
| Gene |
UniProtKB-ID:
MBD4_HUMAN
UniprotKB:
O95243
UniParc:
UPI00001B3D9F,
UPI0000071929,
UPI0000073E6A,
UPI0000684833,
UPI000020A20A
EMBL:
AF120998,
AF494057,
CR450305,
AF120997,
BC011752,
AM180876,
AK303013,
CH471052,
AL449212,
AF072250,
AF120999,
AF114784,
AF532602
Ensembl:
ENSG00000129071
KO:
hsa:8930
|
| Nucleutide sequences |
EMBL-CDS:
AAM00008.1,
AAH11752.1,
CAJ55826.1,
EAW79254.1,
EAW79253.1,
EAW79251.1,
CAG29301.1,
AAD22195.1,
BAG64144.1,
EAW79255.1,
AAD50374.1,
AAP97338.1,
AAC68879.1
Ensembl_TRS:
ENST00000249910,
ENST00000393278,
ENST00000503197,
ENST00000429544,
ENST00000507208
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000422327,
ENSP00000424873,
ENSP00000376959,
ENSP00000249910,
ENSP00000394080
RefSeq:
NP_001263200.1,
NP_001263199.1,
XP_024309578.1,
NP_003916.1,
NP_001263202.1,
NP_001263201.1
|
| Others |
UniRef100:
UniRef100_O95243
UniRef90:
UniRef90_O95243
UniRef50:
UniRef50_O95243
UniGene:
Hs.35947
CCDS:
CCDS63766.1,
CCDS63768.1,
CCDS3058.1,
CCDS63767.1,
CCDS63769.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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