| Type | Description |
|---|---|
| Definition | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:15:00 | The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling. | 31965002 |
| 2017-10-28 12:30:00 | In the light of recent reports of HERC1 mutations in two families with a similar phenotypic presentation, this report reiterates the pathogenic nature and clinical consequences of HERC1 disruption. | 27108999 |
| 2016-07-02 10:58:00 | Biallelic sequence variants in a novel gene (HERC1) are linked to a syndromic form of overgrowth and intellectual disability. | 26138117 |
| 2015-06-27 12:04:00 | Data show that E3 ubiquitin-protein ligase HERC1 interacts with bcl-2 homologous antagonist-killer protein BAK in HPV5 E6-expressing cells that have been damaged by UV. | 25408501 |
| 2010-01-21 00:00:00 | HERC1 overexpression does not stimulate protrusion formation in the absence of AlF(4)(-), in conditions where ARNO does, indicating that HERC1 is not acting as an ARF6-GEF, but instead its recruitment takes place downstream of ARF6 activation | 14960311 |
| Type | IDs |
|---|---|
| Synonymous | MDFPMR, p532, p619 |
| Gene |
UniProtKB-ID:
HERC1_HUMAN,
A0A024R5W0_HUMAN
UniprotKB:
Q15751,
A0A024R5W0
UniParc:
UPI0000212760
EMBL:
AC118274,
BC040929,
AC073167,
U50078,
CH471082
Ensembl:
ENSG00000103657
KO:
hsa:8925
|
| Nucleutide sequences |
EMBL-CDS:
AAH40929.1,
AAD12586.1,
EAW77656.1,
EAW77655.1
Gene_ORFName:
hCG_1818283
Ensembl_TRS:
ENST00000443617
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000390158
RefSeq:
XP_016878194.1,
XP_016878188.1,
XP_016878189.1,
XP_016878190.1,
XP_016878193.1,
XP_016878195.1,
XP_016878192.1,
NP_003913.3,
XP_016878191.1
|
| Others |
UniRef100:
UniRef100_Q15751
UniRef90:
UniRef90_Q15751
UniRef50:
UniRef50_Q15751
UniGene:
Hs.210385
CCDS:
CCDS45277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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