| Type | Description |
|---|---|
| Definition | HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 10:49:00 | The increased expression of HERC3 in glioblastoma associated with poor clinical outcome. In experimental models, autophagy inducers upregulated HERC3. | 30862693 |
| 2019-10-19 11:23:00 | The data illuminate a novel axis regulating cell senescence: DeltaNp63alpha stimulates transcription of E3 ligase HERC3, which mediates ubiquitination of c-Myc modulator MM1 and targets it to proteasomal degradation; subsequently, c-Myc is derepressed by DeltaNp63alpha, thereby cell senescence is modulated by this axis. | 29880857 |
| 2016-04-02 11:25:00 | HERC3 negatively regulates NF-kappaB signaling by enhancing RelA subunit degradation. | 26476452 |
| 2012-03-31 11:48:00 | we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability | 22124266 |
| 2010-06-30 22:06:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HERC3_HUMAN,
B4DK41_HUMAN
UniprotKB:
Q15034,
B4DK41
UniParc:
UPI00017A71AD,
UPI000012C614,
UPI000007431B
EMBL:
AC108065,
BC038960,
AC083829,
AC098582,
AK289990,
CH471057,
D25215,
AK296379
Ensembl:
ENSG00000138641
KO:
hsa:8916
|
| Nucleutide sequences |
EMBL-CDS:
EAX06024.1,
BAF82679.1,
BAA04945.2,
AAH38960.1,
BAG59053.1
Ensembl_TRS:
ENST00000264345,
ENST00000407637,
ENST00000402738
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264345,
ENSP00000385684,
ENSP00000384005
RefSeq:
XP_005263388.1,
NP_001362408.1,
NP_001362407.1,
NP_001362411.1,
NP_001305434.1,
XP_005263384.1,
XP_011530699.1,
NP_001362410.1,
XP_016864297.1,
NP_055421.1,
NP_001258531.1,
NP_001362406.1,
NP_001362409.1,
NP_001362412.1,
XP_005263387.1,
XP_005263389.1
|
| Others |
UniRef100:
UniRef100_Q15034
UniRef90:
UniRef90_Q15034
UniRef50:
UniRef50_Q15034
UniGene:
Hs.35804
CCDS:
CCDS34028.1,
CCDS82939.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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