| Type | Description |
|---|---|
| Definition | immediate early response 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-01 11:03:00 | Overexpression of GAS5 enhanced the sensitivity of cervical cancer cells to radiation treatment via up-regulating IER3 through miR-106b. | 30579899 |
| 2018-12-22 10:03:00 | Our findings suggest for the first time that the increased expression of IER3 protein may promote the aggressive progression of BCa. Importantly, IER3 may be a potential prognostic marker for BCa patients. | 30249226 |
| 2017-09-02 12:09:00 | we determined the molecular mechanism responsible for IER3 degradation, involving a ternary complex of IER3, MDM2 and FHL2, which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein | 26973248 |
| 2017-06-03 11:36:00 | Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. | 27890615 |
| 2017-05-20 12:27:00 | Study characterized IEX-1's expression and function in rheumatoid arthritis synovial fibroblasts and showed that IEX-1 is highly expressed in RA-SFs and negatively regulates RA-SF activation. | 27736946 |
| Type | IDs |
|---|---|
| Synonymous | DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 |
| Gene |
UniProtKB-ID:
IEX1_HUMAN,
A0A1U9X7X2_HUMAN
UniprotKB:
P46695,
A0A1U9X7X2
UniParc:
UPI00001AFA8D
EMBL:
X96438,
BT006703,
KY500405,
S81914,
AL662797,
Y14551,
BC005080,
BA000025,
BC000844
Ensembl:
ENSG00000235030,
ENSG00000230128,
ENSG00000227231,
ENSG00000137331,
ENSG00000237155,
ENSG00000206478
KO:
hsa:8870
|
| Nucleutide sequences |
EMBL-CDS:
BAB63319.1,
AAH00844.1,
AAP35349.1,
AAB36278.1,
AAH05080.1,
CAA65304.1,
CAA74886.1,
AQY76892.1
Ensembl_TRS:
ENST00000435856,
ENST00000259874,
ENST00000450236,
ENST00000439190,
ENST00000383560,
ENST00000416884
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000412283,
ENSP00000373054,
ENSP00000259874,
ENSP00000398139,
ENSP00000397956,
ENSP00000406245
RefSeq:
NP_003888.2
|
| Others |
UniRef100:
UniRef100_P46695
UniRef90:
UniRef90_P46695
UniRef50:
UniRef50_P46695
UniGene:
Hs.76095
CCDS:
CCDS4689.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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