| Type | Description |
|---|---|
| Definition | 3-oxoacyl-ACP reductase FabG |
| Date | Results | Publications |
|---|---|---|
| 2014-12-06 13:00:00 | study identified the mabA(g609a) silent mutation in a significant number of isoniazid (INH)resistant Mtb clinical isolates without known INH resistance mutations; findings show here that the mabA(g609a) mutation resulted in the upregulation of inhA | 24354762 |
| 2014-07-26 11:52:00 | a new mutation in mabA, Thr4Ile, was identified; a putative role for this mutation in the process of diminishing susceptibility to isoniazid is evaluated | 23973657 |
| 2013-05-25 11:09:00 | Data suggest that a better understanding of the mode of action of beta-ketoacyl-ACP Reductase (MabA) should be useful to guide the rational (function-based) design of inhibitors of MabA enzyme activity and used as lead compounds with anti-TB action. | 23006410 |
| 2012-09-29 11:07:00 | A mountable FabG4:NADH complex crystal diffracted to 2.59 A resolution and belonged to space group P1, with unit-cell parameters a = 63.07, b = 71.03, c = 92.92 A, alpha = 105.02, beta = 97.06, gamma = 93.66 degrees | 22750865 |
| 2010-01-21 00:00:00 | A mechanism of substrate binding to MabA is proposed that indicates positive cooperativity in NADPH binding, with two forms of free enzyme present in solution, and a reduced affinity of both substrates for the monomeric form of MabA. | 18155153 |
| Type | IDs |
|---|---|
| Synonymous | mabA |
| Gene |
UniProtKB-ID:
FABG_MYCTU
UniprotKB:
P9WGT3
UniParc:
UPI000012A460
EMBL:
AL123456,
U66801
EnsemblGenome:
Rv1483
KO:
mtv:RVBD_1483,
mtu:Rv1483
|
| Nucleutide sequences |
EMBL-CDS:
AAC69639.1,
CCP44243.1
Gene_ORFName:
MTCY277.04
EnsemblGenome_TRS:
CCP44243
|
| Protein sequencees |
EnsemblGenome_PRO:
CCP44243
|
| Others |
UniRef100:
UniRef100_P0A5Y5
UniRef90:
UniRef90_P0A5Y5
UniRef50:
UniRef50_P0A5Y5
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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