| Type | Description |
|---|---|
| Definition | molecular chaperone GroEL |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:56:00 | Interaction mechanism of Mycobacterium tuberculosis GroEL2 protein with macrophage Lectin-like, oxidized low-density lipoprotein receptor-1: An integrated computational and experimental study. | 33031906 |
| 2018-08-25 10:37:00 | Here the authors present data showing that GroEL2, a substrate of Hip1, modulates dendritic cell functions. The full-length GroEL2 protein elicited robust proinflammatory responses from dendritic cells and promoted their maturation and antigen presentation to T cells. In contrast, the cleaved form of GroEL2, which predominates in Mycobacterium tuberculosis, was poorly immunostimulatory. | 29133346 |
| 2014-06-21 10:17:00 | hsp65 Nested PCR-PRA was shown to be a fast and reliable assay for diagnosing tuberculosis | 24260739 |
| 2011-11-12 10:26:00 | Data suggest that cleavage of HSP65 by matrix metalloproteinases, including MMP-9, to create immunogenic peptides contributes to complex immunomodulatory interplay in course of TB infection. [HSP65] | 21752195 |
| 2010-01-21 00:00:00 | Findings reveal a unique role of the Mycobacterium tuberculosis heat shock protein 60 favouring development of Th2 type response by upregulating surface expression of TLR2 on macrophages which could be a survival strategy adopted by the bacilli. | 18419772 |
| Type | IDs |
|---|---|
| Synonymous | groEL-2, groL2, hsp60, hsp65 |
| Gene |
UniProtKB-ID:
CH602_MYCTU
UniprotKB:
P9WPE7
UniParc:
UPI000002C36C
EMBL:
M15467,
AL123456,
U17957,
U55825,
S76635
EnsemblGenome:
Rv0440
KO:
mtu:Rv0440,
mtv:RVBD_0440
|
| Nucleutide sequences |
EMBL-CDS:
AAA88232.1,
AAC44458.1,
AAB39076.1,
AAP31974.1,
CCP43171.1
Gene_ORFName:
MTV037.04
EnsemblGenome_TRS:
CCP43171
|
| Protein sequencees |
EnsemblGenome_PRO:
CCP43171
|
| Others |
UniRef100:
UniRef100_A5TZG6
UniRef90:
UniRef90_A0QQU5
UniRef50:
UniRef50_P42384
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
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