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8854 ALDH1A2

8854

ALDH1A2

aldehyde dehydrogenase 1 family member A2

protein-coding

Homo sapiens

基因描述

Type Description
Definition aldehyde dehydrogenase 1 family member A2

研究结论

Date Results Publications
2020-05-16 12:44:00 ALDH1A2 and ALDH1A3 showed higher catalytic efficiency for all-trans-retinaldehyde. Magnesium inhibited ALDH1A1 and ALDH1A2, while it activated ALDH1A3. 31923393
2019-07-27 13:00:00 The ALDH1A2 locus seems to increase the risk of hand osteoarthritis through decreased expression of ALDH1A2 in joint tissues, with the effect dependent on single-nucleotide polymorphism rs12915901. 29732726
2018-04-07 10:55:00 The authors findings indicate that the SNP rs4238326 in ALDH1A2 gene may potentially modify individual susceptibility to knee OA in the Chinese population. 28089900
2018-01-06 10:50:00 high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients 27015121
2017-05-20 14:49:00 Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional. 27001866

名称对应

Type IDs
Synonymous RALDH(II), RALDH2, RALDH2-T
Gene
UniProtKB-ID: AL1A2_HUMAN
UniprotKB: O94788
UniParc: UPI000006F865, UPI0000E01FCE, UPI00001678B4, UPI000013CC95
EMBL: AB015228, AB015226, AC084781, AK128709, AC012653, AK303057, AB015227, BC030589, DQ322171, AL110299, AC018904, AC066616, AC025431
Ensembl: ENSG00000128918
KO: hsa:8854
Nucleutide sequences
EMBL-CDS: BAG64174.1, ABC40749.1, BAA34786.1, AAH30589.1, BAA34785.1, BAA34787.1, CAB53740.2, BAG54714.1
Ensembl_TRS: ENST00000559517, ENST00000537372, ENST00000347587, ENST00000249750
Protein sequencees
Ensembl_PRO: ENSP00000309623, ENSP00000438296, ENSP00000249750, ENSP00000453408
RefSeq: NP_003879.2, NP_001193826.1, NP_733797.1, NP_733798.1
Others
UniRef100: UniRef100_O94788
UniRef90: UniRef90_Q62148
UniRef50: UniRef50_Q62148
UniGene: Hs.643455
CCDS: CCDS10163.1, CCDS45266.1, CCDS10164.1, CCDS55968.1

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