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8852 AKAP4

8852

AKAP4

A-kinase anchoring protein 4

protein-coding

Homo sapiens

基因描述

Type Description
Definition A-kinase anchoring protein 4

研究结论

Date Results Publications
2020-05-09 13:47:00 A-kinase anchor protein 4 downregulation inhibits various malignant properties and enhances the cytotoxic effect of paclitaxel, and this combinatorial approach could be useful for triple-negative breast cancer treatment. 32342732
2019-12-21 12:02:00 Knockdown of AKAP4 inhibits hypoxia-induced epithelial-mesenchymal transition in human gastric cancer cells, at least in part, via inactivation of the Wnt/beta-catenin signaling pathway. 30145836
2019-12-14 12:36:00 pro-AKAP4 protein in the fibrous sheath of human ejaculated spermatozoa and in elongating/elongated spermatids in the human testis. In normozoospermia, there were high interindividual variations in pro-AKAP4 levels, and these latter were associated with sperm motility. 29984477
2019-09-07 11:25:00 This study showed the role of Lactobacilli in down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes. Such expression change might be involved in the anticancer effects of these Lactobacilli. The underlying mechanisms of these observations are not clear but epigenetic modulatory mechanisms may participate in this process. 30545223
2018-11-03 11:54:00 High AKAP4 expression is associated with reduced sperm motility. 29581387

名称对应

Type IDs
Synonymous AKAP 82, AKAP-4, AKAP82, CT99, FSC1, HI, PRKA4, hAKAP82, p82
Gene
UniProtKB-ID: AKAP4_HUMAN, A0A384MQY7_HUMAN
UniprotKB: Q5JQC9, A0A384MQY7
UniParc: UPI000013DA96, UPI0000161A4C
EMBL: CH471180, Y15195, FO393402, GQ891359, BC126252, AF072756, BC126250
Ensembl: ENSG00000147081
KO: hsa:8852
Nucleutide sequences
EMBL-CDS: CAA75494.1, AAI26251.1, AAI26253.1, AAC79433.1, EAW89926.1, ADO22221.1
Gene_ORFName: hCG_1993017
Ensembl_TRS: ENST00000358526, ENST00000376064
Protein sequencees
Ensembl_PRO: ENSP00000365232, ENSP00000351327
RefSeq: NP_647450.1, NP_003877.2
Others
UniRef100: UniRef100_Q5JQC9
UniRef90: UniRef90_Q5JQC9
UniRef50: UniRef50_Q60662
UniGene: Hs.97633
CCDS: CCDS14330.1, CCDS14329.1

全选

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