| Type | Description |
|---|---|
| Definition | kinase suppressor of ras 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 12:12:00 | Findings demonstrate a role for kinase suppressor of Ras 1 as a positive regulator of neurotensin secretion from human endocrine cells and indicate that this effect is mediated by the extracellular signal-regulated kinase 1 and 2 signaling pathway. | 30917119 |
| 2019-09-21 10:54:00 | Erbin interacted with kinase suppressor of Ras 1 (KSR1) and displaced it from the RAF/MEK/ERK complex to prevent signal propagation..These findings establish the scaffold protein Erbin as a negative regulator of EMT and tumorigenesis in colorectal cancer through direct suppression of Akt and RAS/RAF signaling | 29980571 |
| 2018-07-14 11:01:00 | findings demonstrate that KSR-MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts and challenge the accepted role of KSR as a scaffold for MEK recruitment to RAF | 29433126 |
| 2018-07-14 10:06:00 | Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer | 29596465 |
| 2017-10-28 13:21:00 | praja2 regulates KSR1 stability and mitogenic signaling. | 27195677 |
| Type | IDs |
|---|---|
| Synonymous | KSR, RSU2 |
| Gene |
UniProtKB-ID:
KSR1_HUMAN
UniprotKB:
Q8IVT5
UniParc:
UPI0000D622E4,
UPI00015DFB00,
UPI00005B2F0C,
UPI0000D622E3
EMBL:
BC042106,
AC069366,
U43586,
AC015688
Ensembl:
ENSG00000141068
KO:
hsa:8844
|
| Nucleutide sequences |
EMBL-CDS:
AAC50354.1,
AAH42106.1
Ensembl_TRS:
ENST00000509603,
ENST00000398988
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381958,
ENSP00000438795
RefSeq:
XP_016880761.1,
XP_006722217.1,
XP_016880756.1,
XP_016880765.1,
XP_016880764.1,
XP_016880767.1,
XP_011523732.1,
NP_055053.1,
XP_016880760.1,
XP_016880769.1,
XP_016880763.1,
XP_016880762.1,
XP_016880759.1,
XP_011523733.1,
XP_011523731.1,
NP_001354739.1,
XP_016880766.1,
XP_016880768.1
|
| Others |
UniRef100:
UniRef100_Q8IVT5
UniRef90:
UniRef90_Q8IVT5
UniRef50:
UniRef50_Q61097
UniGene:
Hs.133534
CCDS:
CCDS58532.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员