| Type | Description |
|---|---|
| Definition | cellular repressor of E1A stimulated genes 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-16 11:18:00 | Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] | 27784214 |
| 2016-10-08 11:27:00 | These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. | 26722374 |
| 2015-02-14 10:35:00 | Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. | 24896341 |
| 2014-03-22 10:37:00 | The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. | 24018888 |
| 2013-12-07 11:23:00 | CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. | 23580165 |
| Type | IDs |
|---|---|
| Synonymous | CREG |
| Gene |
UniProtKB-ID:
CREG1_HUMAN
UniprotKB:
O75629
UniParc:
UPI0000047822
EMBL:
AK095456,
AK315497,
CH471067,
BC008628,
AL031733,
AY359071,
BC006786,
AF084523
Ensembl:
ENSG00000143162
KO:
hsa:8804
|
| Nucleutide sequences |
EMBL-CDS:
AAC34861.1,
EAW90795.1,
BAC04550.1,
BAG37881.1,
AAH06786.1,
AAQ89430.1,
AAH08628.1
Gene_ORFName:
UNQ727/PRO1409
Ensembl_TRS:
ENST00000370509
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359540
RefSeq:
NP_003842.1
|
| Others |
UniRef100:
UniRef100_O75629
UniRef90:
UniRef90_O75629
UniRef50:
UniRef50_O75629
UniGene:
Hs.5710
CCDS:
CCDS1262.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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