| Type | Description |
|---|---|
| Definition | harakiri, BCL2 interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. | 32900773 |
| 2020-09-05 13:59:00 | Characterization of an alternative BAK-binding site for BH3 peptides. | 32620849 |
| 2020-04-18 10:57:00 | In individuals with susceptible genetic backgrounds, Coxsackie B viral infection alters the epigenome to activate the pathological pathways leading to polymyositis-dermatomyositis via mitochondrial dysfunction and HRK up-regulation. | 31135059 |
| 2018-04-14 11:25:00 | The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in glioblastoma multiforme cells. | 28661478 |
| 2017-06-10 12:13:00 | miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis. | 27737950 |
| Type | IDs |
|---|---|
| Synonymous | DP5, HARAKIRI |
| Gene |
UniProtKB-ID:
HRK_HUMAN
UniprotKB:
O00198
UniParc:
UPI000012CBC6
EMBL:
U76376,
AC083806
Ensembl:
ENSG00000135116
KO:
hsa:8739
|
| Nucleutide sequences |
EMBL-CDS:
AAC34931.1
Ensembl_TRS:
ENST00000257572
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000257572
RefSeq:
NP_003797.1,
XP_016875635.1
|
| Others |
UniRef100:
UniRef100_O00198
UniRef90:
UniRef90_O00198
UniRef50:
UniRef50_O00198
UniGene:
Hs.87247
CCDS:
CCDS9181.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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