| Type | Description |
|---|---|
| Definition | CASP2 and RIPK1 domain containing adaptor with death domain |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:41:00 | Twenty two patients were identified with the c.509G>A p.(Arg170His) homozygous variant in ASP2 and RIPK1 domain containing adaptor with death domain protein CRADD (CRADD). | 30914828 |
| 2017-12-02 11:39:00 | Whole exome sequencing (WES) of an affected fetus, and subsequent Sanger sequencing of the second fetus, revealed a homozygous frameshift variant in CRADD, which encodes an adaptor protein that interacts with PIDD and caspase-2 to initiate apoptosis | 28686357 |
| 2017-05-20 11:52:00 | The megalencephaly, lissencephaly variant, and intellectual disability associated with loss of CRADD/caspase-2-mediated apoptosis imply a role for CRADD/caspase-2 signaling in development of the human cerebral cortex. | 27773430 |
| 2017-02-04 11:48:00 | The adaptor molecule RAIDD coordinates IKKepsilon and IRF7 interaction to ensure efficient expression of type I interferon. | 27606466 |
| 2015-02-21 10:17:00 | define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists | 24958727 |
| Type | IDs |
|---|---|
| Synonymous | MRT34, RAIDD |
| Gene |
UniProtKB-ID:
CRADD_HUMAN,
Q8IY43_HUMAN,
F8VVY5_HUMAN,
Q53XL1_HUMAN,
B4DJT6_HUMAN,
F5H7C2_HUMAN,
F8VV49_HUMAN
UniprotKB:
P78560,
Q8IY43,
F8VVY5,
Q53XL1,
B4DJT6,
F5H7C2,
F8VV49
UniParc:
UPI00001FB2C9,
UPI0001914B90,
UPI00001283AA,
UPI00000742D6,
UPI0000E5988D,
UPI00017A7363,
UPI00020655DE
EMBL:
AC025261,
BC017042,
U79115,
BC037905,
AK296225,
AC012464,
CR407643,
BT009837,
CH471054,
KF495766,
AK314861,
U84388,
AK294986,
AC012085
Ensembl:
ENSG00000169372
KO:
hsa:8738
|
| Nucleutide sequences |
EMBL-CDS:
AAC50952.1,
AAH17042.1,
BAH11941.1,
AAB42217.1,
AAH37905.1,
CAG28571.1,
AAP88839.1,
BAG37377.1,
EAW97497.1,
BAG58948.1
Gene_ORFName:
hCG_40089
Ensembl_TRS:
ENST00000542893,
ENST00000332896,
ENST00000551065,
ENST00000552983,
ENST00000548483,
ENST00000552033
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000448425,
ENSP00000327647,
ENSP00000439068,
ENSP00000449570,
ENSP00000448685,
ENSP00000449664
RefSeq:
NP_001307029.1,
NP_001317055.1,
NP_003796.1,
XP_016875634.1,
NP_001307030.1,
XP_016875632.1,
NP_001307028.1,
XP_024305020.1,
XP_016875633.1
|
| Others |
UniRef100:
UniRef100_F5H7C2,
UniRef100_Q8IY43,
UniRef100_B4DJT6,
UniRef100_F8VV49,
UniRef100_P78560,
UniRef100_F8VVY5
UniRef90:
UniRef90_A0A2I3LR23,
UniRef90_P78560,
UniRef90_A0A2I3NCC3,
UniRef90_G1R151
UniRef50:
UniRef50_G1R151,
UniRef50_P78560,
UniRef50_D3ZB14,
UniRef50_A0A2I3LR23
UniGene:
Hs.38533,
Hs.591016
CCDS:
CCDS9048.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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