| Type | Description |
|---|---|
| Definition | tyrosine kinase non receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 11:33:00 | TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut. | 30320600 |
| 2019-02-09 11:21:00 | the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied. | 28631188 |
| 2014-04-05 10:57:00 | The activated TNK1 potentiates signaling through dual phosphorylation of at tyrosine 701 and serine 727 amino acid positions. | 24449862 |
| 2011-10-22 10:11:00 | The application of functional genomics by using screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells. | 21536687 |
| 2010-09-15 22:05:00 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | 20534741 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TNK1_HUMAN
UniprotKB:
Q13470
UniParc:
UPI000013F1D0,
UPI000007424D
EMBL:
BC035782,
U43408,
AF097738
Ensembl:
ENSG00000283781,
ENSG00000174292
KO:
hsa:8711
|
| Nucleutide sequences |
EMBL-CDS:
AAC50427.1,
AAC99412.1,
AAH35782.1
Ensembl_TRS:
ENST00000639430,
ENST00000570896,
ENST00000576812,
ENST00000639010
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458834,
ENSP00000491136,
ENSP00000491712,
ENSP00000459799
RefSeq:
XP_011522347.1,
NP_001238831.1,
XP_011522349.1,
XP_011522348.1,
XP_011522350.1,
NP_003976.2
|
| Others |
UniRef100:
UniRef100_Q13470
UniRef90:
UniRef90_Q13470
UniRef50:
UniRef50_Q13470
UniGene:
Hs.203420,
Hs.739114
CCDS:
CCDS45602.1,
CCDS58510.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 30320600 |
Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure. J. Clin. Invest. Milena Armacki , Anna Katharina Trugenberger , Ann K Ellwanger , Tim Eiseler , Christiane Schwerdt , Lucas Bettac , Dominik Langgartner , Ninel Azoitei , Rebecca Halbgebauer , Rüdiger Groà , Tabea Barth , André Lechel , Benjamin M Walter , Johann M Kraus , Christoph Wiegreffe , Johannes Grimm , Annika Scheffold , Marlon R Schneider , Kenneth Peuker , Sebastian ZeiÃig , Stefan Britsch , Stefan Rose-John , Sabine Vettorazzi , Eckhart Wolf , Andrea Tannapfel , Konrad Steinestel , Stefan O Reber , Paul Walther , Hans A Kestler , Peter Radermacher , Thomas Fe Barth , Markus Huber-Lang , Alexander Kleger , Thomas Seufferlein |
2018-11-01 | - |
| 28631188 |
Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease. Mol Neurobiol Davide Seripa , Francesco Panza , Giulia Paroni , Grazia D'Onofrio , Paola Bisceglia , Carolina Gravina , Maria Urbano , Madia Lozupone , Vincenzo Solfrizzi , Alessandra Bizzarro , Virginia Boccardi , Chiara Piccininni , Antonio Daniele , Giancarlo Logroscino , Patrizia Mecocci , Carlo Masullo , Antonio Greco |
2018-05-01 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 25852190 |
Sci Signal Jonathan So , Adrian Pasculescu , Anna Y Dai , Kelly Williton , Andrew James , Vivian Nguyen , Pau Creixell , Erwin M Schoof , John Sinclair , Miriam Barrios-Rodiles , Jun Gu , Aldis Krizus , Ryan Williams , Marina Olhovsky , James W Dennis , Jeffrey L Wrana , Rune Linding , Claus Jorgensen , Tony Pawson , Karen Colwill |
2015-04-07 | - |
| 24449862 |
Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1. Proc. Natl. Acad. Sci. U.S.A. Ee Lyn Ooi , Stephanie T Chan , Noell E Cho , Courtney Wilkins , Jessica Woodward , Meng Li , Ushio Kikkawa , Timothy Tellinghuisen , Michael Gale , Takeshi Saito |
2014-02-04 |
Stat1,
Tnk1,
STAT1,
TNK1
|
| 22939624 |
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell Mikko Taipale , Irina Krykbaeva , Martina Koeva , Can Kayatekin , Kenneth D Westover , Georgios I Karras , Susan Lindquist |
2012-08-31 |
NR1H3,
TRIM10,
SGK2,
PREB,
CDK3,
TNK2,
CDK4,
CDK6,
CDK7,
CDK9,
LOC400927-CSNK1E,
PCGF3,
TESK2,
MERTK,
KAT5,
CEBPE,
NPRL2,
CAMKK2,
MAP3K2,
FASTK,
RCBTB2,
PIM2,
WWP1,
CHEK1,
CDC37,
MAP4K1,
IRAK3,
TP53RK,
STK38,
KLHL32,
KLHL29,
FBXO17,
CLK2,
CLK3,
FBXO27,
ASB17,
RNF19B,
ACVR1C,
GRK7,
MAP3K8,
ASB6,
MYO3B,
RAB40A,
CSF1R,
FBXL14,
CSNK1A1,
CSNK1E,
HIPK4,
PDIK1L,
KLHL23,
SH3RF2,
SGK223,
DAPK3,
DCLK2,
ZBTB49,
DLX6,
DMPK,
EGFR,
EPHA2,
EPHA1,
EPHA4,
EPHB1,
EPHB6,
ERBB2,
ERBB3,
ERBB4,
AKT2,
ESR1,
PTK2B,
FBXL13,
FER,
FES,
MAPK15,
FGFR1,
FGFR3,
FGR,
ICK,
TRIM32,
TCF25,
STK38L,
FOXM1,
MAST2,
PASK,
LARP4B,
FBXO28,
DTX4,
FLT4,
ZC3H7B,
FBXW11,
TRIM2,
SF3B3,
TSSK2,
SGK3,
ALK,
FRK,
ABL1,
FYN,
KLHL34,
FBXL2
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21536687 |
Mol. Cancer Res. Meredith C Henderson , Irma M Gonzales , Shilpi Arora , Ashish Choudhary , Jeffrey M Trent , Daniel D Von Hoff , Spyro Mousses , David O Azorsa |
2011-06-01 |
TNK1
|
| 20534741 |
Hum Mol Genet Jason J Corneveaux , Amanda J Myers , April N Allen , Jeremy J Pruzin , Manuel Ramirez , Anzhelika Engel , Michael A Nalls , Kewei Chen , Wendy Lee , Kendria Chewning , Stephen E Villa , Hunsar B Meechoovet , Jill D Gerber , Danielle Frost , Hollie L Benson , Sean O'Reilly , Lori B Chibnik , Joshua M Shulman , Andrew B Singleton , David W Craig , Kendall R Van Keuren-Jensen , Travis Dunckley , David A Bennett , Philip L De Jager , Christopher Heward , John Hardy , Eric M Reiman , Matthew J Huentelman |
2010-08-15 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
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