| Type | Description |
|---|---|
| Definition | potassium two pore domain channel subfamily K member 5 |
| Date | Results | Publications |
|---|---|---|
| 2018-11-10 12:22:00 | mutations in the promoter region of the TWIK-related acid-sensitive K(+) channel 2 (TASK-2) gene did not result in hypertension or primary aldosteronism (PA) during long-term follow-up in healthy participants thus they do not seem to be a factor in causing PA by themselves. | 29293917 |
| 2018-08-11 10:19:00 | As a novel finding, our study suggests a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, our findings confirm an association between the SH2B3-locus and platelet count. | 28865245 |
| 2017-09-16 10:59:00 | In human aldosterone-producing adrenocortical cancer cell lines, roxithromycin inhibited KCNJ5MUT-induced induction of CYP11B2 (encoding aldosterone synthase) expression and aldosterone production. | 28604387 |
| 2017-09-09 10:44:00 | HLA-DQB1*06:02 does not seem to be associated with hypoxic ventilatory response or hypercapnic ventilatory response; however there are point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and hypercapnic ventilatory response | 28045995 |
| 2017-07-08 12:09:00 | These results therefore provide further structural and functional insights into the possible pathophysiological effects of this missense variant in TASK-2. | 27228168 |
| Type | IDs |
|---|---|
| Synonymous | K2p5.1, KCNK5b, TASK-2, TASK2 |
| Gene |
UniProtKB-ID:
KCNK5_HUMAN,
A0A024RD32_HUMAN,
A0A0B6VPR3_HUMAN
UniprotKB:
O95279,
A0A024RD32,
A0A0B6VPR3
UniParc:
UPI000003AFB5,
UPI0003EB0009
EMBL:
BC060793,
EU978936,
AF084830,
AL451185,
AB743589,
AK314298,
CH471081,
BC069573
Ensembl:
ENSG00000164626
KO:
hsa:8645
|
| Nucleutide sequences |
EMBL-CDS:
BAG36953.1,
ACH86095.1,
AAC79458.1,
EAX03979.1,
AAH60793.1,
AAH69573.1,
EAX03980.1,
BAQ22159.1
Gene_ORFName:
hCG_32352
Ensembl_TRS:
ENST00000359534
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000352527
RefSeq:
XP_006715298.1,
XP_005249513.1,
NP_003731.1
|
| Others |
UniRef100:
UniRef100_O95279
UniRef90:
UniRef90_O95279
UniRef50:
UniRef50_O95279
UniGene:
Hs.444448
CCDS:
CCDS4841.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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