| Type | Description |
|---|---|
| Definition | 3-phosphatidylinositol 3-phosphatase |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 11:58:00 | Phosphatidylinositol 3,4,5-trisphosphate (PIP3) suppresses the PIP3 phosphatase (PTEN) binding site required for stable PTEN membrane binding. Mutual inhibition between PIP3 and PTEN provides a mechanistic basis for bistability underlying the strict spatial separation between PIP3 and PTEN. The PTEN binding site also mediates the suppression of PTEN membrane localization in chemotactic signaling. | 30367048 |
| 2017-08-05 11:54:00 | Asymmetric Ras activation in turning protrusions underscores that gradients can be sensed locally and translated into orientation. Different to cells of normal size, the polarity of large cells is not linked to an increasing front-to-tail gradient of the PIP3-phosphatase PTEN. | 27505897 |
| 2016-07-13 11:55:00 | PTEN is involved in the regulation of lateral pseudopod formation, a process essential for locomotion and chemotaxis, but not for directional sensing. | 17623773 |
| 2015-12-05 11:33:00 | Studied PTEN and show positively charged residues located in the calpha2 helix of the C2 domain are necessary for the membrane localization of PTEN via stable electrostatic interactions in Dictyostelium discoideum. | 25211206 |
| Type | IDs |
|---|---|
| Synonymous | DDBDRAFT_0191093, DDBDRAFT_0218851, DDB_0191093, DDB_0218851 |
| Gene |
UniProtKB-ID:
PTEN_DICDI
UniprotKB:
Q8T9S7
UniParc:
UPI000007605B
EMBL:
AAFI02000089,
AF467431,
AF483827
EnsemblGenome:
DDB_G0286557
KO:
ddi:DDB_G0286557
|
| Nucleutide sequences |
EMBL-CDS:
AAL75566.1,
EAL64034.1,
AAL99958.1
Gene_ORFName:
DDB_G0286557
EnsemblGenome_TRS:
EAL64034
|
| Protein sequencees |
EnsemblGenome_PRO:
EAL64034
RefSeq:
XP_637576.1
|
| Others |
UniRef100:
UniRef100_Q8T9S7
UniRef90:
UniRef90_Q8T9S7
UniRef50:
UniRef50_Q8T9S7
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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