| Type | Description |
|---|---|
| Definition | phospholipid phosphatase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-26 13:11:00 | Roles for lysophosphatidic acid signaling in vascular development and disease. | 32376340 |
| 2020-05-16 10:19:00 | Findings indicate that up-regulation of PLPP3 during inflammation and atherosclerosis results from canonical activation of the NF-kappaB signaling cascade to increase PLPP3 expression through nuclear import and binding of RelA and RelB transcription factors to the PLPP3 promoter and suggest a mechanism by which the LPP3 substrate, LPA, can regulate PLPP3 expression. | 31362988 |
| 2019-11-16 11:13:00 | DNA methylation of a MIR-based enhancer downregulates the expression of PLPP3 and promotes the mineralization of the aortic valve in calcific aortic valve disease. | 29726894 |
| 2019-08-10 12:42:00 | ENPP2 was in silico discovered to be genetically altered in some patients with lung cancer, whereas increased autotaxin (ATX) staining and activity were detected in patients and mouse models, accompanied by a downregulation of PLPP3 expression. Most importantly, genetic deletion of Enpp2 or Lpar1 in mice resulted in disease attenuation, thus confirming a pro-carcinogenic role of ATX/LPA in the lung. | 29724718 |
| 2018-06-09 12:11:00 | LPP3 is the key enzyme in the breakdown of LPA by melanoma cells. | 28871044 |
| Type | IDs |
|---|---|
| Synonymous | Dri42, LPP3, PAP2B, PPAP2B, VCIP |
| Gene |
UniProtKB-ID:
PLPP3_HUMAN
UniprotKB:
O14495
UniParc:
UPI000006F261
EMBL:
BT019589,
AK312439,
U79294,
BC009196,
AF017786,
CH471059,
AF043329,
AB000889,
AF480883
Ensembl:
ENSG00000162407
KO:
hsa:8613
|
| Nucleutide sequences |
EMBL-CDS:
BAA22594.1,
AAC63433.1,
AAH09196.1,
AAD02271.1,
EAX06651.1,
AAB50222.1,
AAO84481.1,
BAG35348.1,
AAV38396.1,
EAX06652.1,
EAX06653.1
Ensembl_TRS:
ENST00000371250
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360296
RefSeq:
NP_003704.3
|
| Others |
UniRef100:
UniRef100_O14495
UniRef90:
UniRef90_O14495
UniRef50:
UniRef50_O14495
UniGene:
Hs.405156,
Hs.619002
CCDS:
CCDS604.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员