| Type | Description |
|---|---|
| Definition | bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:38:00 | in addition to Dna2 phosphorylation described previously, Dna2 sumoylation is required for the homeostasis of the Dna2 protein function to promote genome stability | 31098407 |
| 2019-08-31 11:31:00 | By conditionally depleting lagging-strand nucleases and directly analyzing Okazaki fragments synthesized in vivo in Saccharomyces cerevisiae, we conduct a systematic evaluation of the impact of Rad27, Dna2 and Exo1 on lagging-strand synthesis. We find that Rad27 processes the majority of lagging-strand flaps, with a significant additional contribution from Exo1 but not from Dna2. | 30541106 |
| 2019-06-24 08:00:00 | presentation of a model in which alternative processing of DNA structures arising in Dna2-deficient cells can result in the release of DNA fragments and their capture at double strand breaks (DSBs); similar DNA insertions at DSBs are expected to occur in any cells with linear extrachromosomal DNA fragments | 30518856 |
| 2019-06-01 12:28:00 | DNA nick created by MRX-Sae2 at Ku-blocked DNA double-strand breaks ends can serve as the entry site for Exo1 or Sgs1-Dna2. | 30224356 |
| 2018-12-22 10:45:00 | Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement. | 30446656 |
| Type | IDs |
|---|---|
| Synonymous | WEB2 |
| Gene |
UniProtKB-ID:
DNA2_YEAST
UniprotKB:
P38859
UniParc:
UPI000005304D
EMBL:
U00027,
BK006934
EnsemblGenome:
YHR164C
KO:
sce:YHR164C
|
| Nucleutide sequences |
EMBL-CDS:
AAB68010.1,
DAA06857.1
EnsemblGenome_TRS:
YHR164C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YHR164C
RefSeq:
NP_012034.1
|
| Others |
UniRef100:
UniRef100_P38859
UniRef90:
UniRef90_P38859
UniRef50:
UniRef50_P38859
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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