| Type | Description |
|---|---|
| Definition | Lam4p |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:12:00 | Large-scale atomistic molecular dynamics simulations reveal that sterol egress involves widening of the fracture, penetration of water into the cavity, and consequent destabilization of the bound sterol. The simulations identify polar residues along the fracture that are important for sterol release. | 31799930 |
| 2018-12-22 10:50:00 | results suggest that Lam4S2 engages anionic membranes via a basic surface patch, enabling "head-first" entry of sterol into the binding pocket followed by partial closure of the entryway. Reversal of these steps enables sterol egress. | 29463678 |
| 2017-10-07 11:32:00 | Ltc1 and Ltc3/4 function at the vacuole and plasma membrane, respectively, to create membrane domains that partition upstream regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress responses with sterol homeostasis. | 28774891 |
| Type | IDs |
|---|---|
| Synonymous | LTC3 |
| Gene |
UniProtKB-ID:
LAM4_YEAST
UniprotKB:
P38800
UniParc:
UPI000013B2B1
EMBL:
BK006934,
U10556
EnsemblGenome:
YHR080C
KO:
sce:YHR080C
|
| Nucleutide sequences |
EMBL-CDS:
DAA06775.1,
AAB68895.1
EnsemblGenome_TRS:
YHR080C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YHR080C
RefSeq:
NP_011948.1
|
| Others |
UniRef100:
UniRef100_P38800
UniRef90:
UniRef90_P38800
UniRef50:
UniRef50_P38800
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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