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856254 CTF4

856254

CTF4

chromatin-binding protein CTF4

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition chromatin-binding protein CTF4

研究结论

Date Results Publications
2021-03-13 13:16:00 Sen1 Is Recruited to via Ctf4 and Mrc1 and Promotes Genome Stability. 32075754
2020-03-14 10:36:00 Here the authors show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol alpha-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and one Pol alpha-primase into a replication factory. 31589141
2019-04-20 11:29:00 ur results support a model whereby parental (H3-H4)2 complexes displaced from nucleosomes by DNA unwinding at replication forks are transferred by the CMG-Ctf4-Polalpha complex to lagging-strand DNA for nucleosome assembly at the original location. 30244834
2017-09-09 12:04:00 Ctf4 as a key regulator of DNA double strand end resection at arrested forks. End resection also occurs during physiological rDNA amplification even in the presence of Ctf4. Suppression of end resection is thus important for protecting DSBs at arrested forks from chromosome rearrangements. 28525744
2017-09-02 11:01:00 Ctf4-dependent recruitment of Dna2/Tof2 couples other processes to DNA synthesis, including rDNA copy-number regulation. 27397685

名称对应

Type IDs
Synonymous CHL15, POB1
Gene
UniProtKB-ID: CTF4_YEAST
UniprotKB: Q01454
UniParc: UPI000016843A
EMBL: BK006949, U40829, S63246, M94769
EnsemblGenome: YPR135W
KO: sce:YPR135W
Nucleutide sequences
EMBL-CDS: AAA34887.1, DAA11548.1, AAB68276.1, AAB27308.1
Gene_ORFName: P9659.7
EnsemblGenome_TRS: YPR135W_mRNA
Protein sequencees
EnsemblGenome_PRO: YPR135W
RefSeq: NP_015461.1
Others
UniRef100: UniRef100_Q01454
UniRef90: UniRef90_Q01454
UniRef50: UniRef50_Q01454

全选

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研究热度

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