| Type | Description |
|---|---|
| Definition | high-affinity Cu transporter CTR1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:17:00 | EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells. | 31943177 |
| 2020-03-21 11:37:00 | IGF1R prognosticates prolonged survival in HGSOC patients, possibly due to its positive correlation with hCtr1 | 31140856 |
| 2019-05-18 10:57:00 | Rho0 cells demonstrated loss of Sco1, resulting in copper deficiency by lowering copper transporter 1 abundance, via mechanism involving increased turnover due to ubiquitination. These findings reveal that a Sco1-dependent mitochondrial signal regulates cellular cisplatin import and cytotoxicity. | 30041154 |
| 2019-02-23 11:59:00 | Expression of the human copper transporter 1 in SOD1G37R transgenic ALS mice increases copper levels in the spinal cord and restores SOD1 activity. | 29906423 |
| 2018-07-21 12:10:00 | Several biological properties of the GST-hNdCTR1 fusion protein were assessed. It was demonstrated that in cells, the protein was prone to oligomerization, formed inclusion bodies and displayed no toxicity. Treatment of E. coli cells with copper and silver ions reduced cell viability in a dose- and time-dependent manner | 29099786 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
CTR1_YEAST
UniprotKB:
P49573
UniParc:
UPI0000128656
EMBL:
U02511,
AY693062,
U40828,
BK006949
EnsemblGenome:
YPR124W
KO:
sce:YPR124W
|
| Nucleutide sequences |
EMBL-CDS:
AAA17369.1,
AAB68064.1,
DAA11538.1,
AAT93081.1
Gene_ORFName:
P9642.3
EnsemblGenome_TRS:
YPR124W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPR124W
RefSeq:
NP_015449.1
|
| Others |
UniRef100:
UniRef100_P49573
UniRef90:
UniRef90_P49573
UniRef50:
UniRef50_P49573
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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