| Type | Description |
|---|---|
| Definition | SUMO protease ULP1 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 10:43:00 | Authors show that dosage of SUMO isopeptidase, Ulp1, is important for regulation of TPE. Moderate elevation of Ulp1 reduces silencing of both, the euchromatic gene placed proximal to telomeric repeats and the sub-telomeric genes that are silenced by TPE. | 30357586 |
| 2018-12-22 12:06:00 | Mutations or physiological perturbations altering nuclear pore integrity decrease the levels of the nuclear pore complex (NPC)-associated SUMO protease Ulp1 and trigger the accumulation of sumoylated versions of Hek2 unable to bind NPC mRNAs. Study results support the existence of a quality control mechanism involving Ulp1 as a sensor of NPC integrity and Hek2 as a repressor of NPC biogenesis in budding yeast. | 29695777 |
| 2018-03-10 12:03:00 | Detailed comparison of the SUMO-binding activity of the budding yeast protein Ulp1 (ScUlp1) and its ortholog in the thermotolerant yeast Kluyveromyces marxianus, KmUlp1. We find that the catalytic UD domains of both ScUlp1 and KmUlp1 show a high degree of sequence conservation, complement a ulp1Delta mutant in vivo, and process a SUMO precursor in vitro. | 29351565 |
| 2013-12-14 11:26:00 | our data highlight a role for the NPC-associated SUMO protease Ulp1 in regulating the sumoylation of gene-bound transcription regulators. | 24074957 |
| 2012-02-18 10:35:00 | A prominent ~50-kDa sumoylated protein accumulates in a Ulp1 coiled-coil domain mutant; that was identified as Scs2, an endoplasmic reticulum (ER) membrane protein that regulates phosphatidylinositol synthesis and lipid trafficking. | 22025676 |
| Type | IDs |
|---|---|
| Synonymous | NIB1 |
| Gene |
UniProtKB-ID:
ULP1_YEAST
UniprotKB:
Q02724
UniParc:
UPI000004F0A0
EMBL:
BK006949,
U36624
EnsemblGenome:
YPL020C
KO:
sce:YPL020C
|
| Nucleutide sequences |
EMBL-CDS:
DAA11408.1,
AAB68167.1
Gene_ORFName:
LPB11C
EnsemblGenome_TRS:
YPL020C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPL020C
RefSeq:
NP_015305.1
|
| Others |
UniRef100:
UniRef100_Q02724
UniRef90:
UniRef90_Q02724
UniRef50:
UniRef50_Q02724
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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