| Type | Description |
|---|---|
| Definition | iron-binding protein ISU1 |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 11:30:00 | In the absence of Yfh1, Isu1 was found to exist in two forms, one mostly monomeric with limited tendency to dimerize, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1].[Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery. | 28548666 |
| 2017-04-29 10:47:00 | Proteomic and metabolomic comparisons revealed that the xylose-metabolizing mutant strains exhibit altered metabolic pathways relative to the parental strain when grown in xylose. Further analyses revealed that interacting mutations in HOG1 and ISU1 unexpectedly elevated mitochondrial respiratory proteins and enabled rapid aerobic respiration of xylose and other non-fermentable carbon substrates. | 27741250 |
| 2017-01-14 11:52:00 | Isu is a substrate of the Lon-type protease and that it is protected from degradation by Nfs1, the sulfur donor for Fe-S cluster assembly, as well as by Jac1, the J-protein Hsp70 cochaperone that functions in cluster transfer from Isu. Nfs1 and Jac1 variants known to be defective in interaction with Isu were also defective in protecting Isu from degradation. | 26842892 |
| 2016-05-07 11:00:00 | Studied the structure and dynamics of the yeast Isu1-Jac1 complex. | 25973573 |
| 2016-04-30 11:18:00 | The eukaryotic forms are critical for Fe-S cluster assembly whereas prokaryotic forms are more dispensable. We found that a key to this difference is a single amino acid in the scaffold protein Isu1 at position 141. | 25996596 |
| Type | IDs |
|---|---|
| Synonymous | NUA1 |
| Gene |
UniProtKB-ID:
ISU1_YEAST
UniprotKB:
Q03020
UniParc:
UPI00000695B2
EMBL:
BK006949,
U43703
EnsemblGenome:
YPL135W
KO:
sce:YPL135W
|
| Nucleutide sequences |
EMBL-CDS:
AAB68224.1,
DAA11298.1
EnsemblGenome_TRS:
YPL135W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPL135W
RefSeq:
NP_015190.1
|
| Others |
UniRef100:
UniRef100_Q03020
UniRef90:
UniRef90_Q03020
UniRef50:
UniRef50_Q03020
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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