| Type | Description |
|---|---|
| Definition | Nop53p |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:19:00 | the Nop53 is considered the adaptor responsible for recruiting the exosome complex for 7S processing. | 31662437 |
| 2017-12-09 13:13:00 | report the 3.2 A resolution crystal structure of S. cerevisiae Mtr4 bound to the interacting region of Nop53, revealing how the KOW domain of the helicase recognizes the AIM sequence of Nop53 with a network of hydrophobic and electrostatic interactions | 28883156 |
| 2015-11-28 11:30:00 | Study reports the identification of adaptor proteins that recruit the exosome-associated helicase, Mtr4, to unique RNA substrates. Nop53, the yeast homolog of the tumor suppressor PICT1, targets Mtr4 to pre-ribosomal particles for exosome-mediated processing, while a second adaptor Utp18 recruits Mtr4 to cleaved rRNA fragments destined for degradation by the exosome. | 26317469 |
| 2010-01-21 00:00:00 | Nop53p is a late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence. | 16043506 |
| 2010-01-21 00:00:00 | Deletion or mutations within NOP53 cause significant growth defects and display significant 60 S subunit deficiencies, an imbalance in the 40 S:60 S ratio, and defects in progression beyond the 27 S stage of 25 S rRNA maturation during 60 S biogenesis. | 15686447 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
NOP53_YEAST
UniprotKB:
Q12080
UniParc:
UPI000013BD31
EMBL:
U43703,
X96770,
Z73502,
BK006949
EnsemblGenome:
YPL146C
KO:
sce:YPL146C
|
| Nucleutide sequences |
EMBL-CDS:
CAA97850.1,
AAB68216.1,
CAA65547.1,
DAA11289.1
Gene_ORFName:
P2610,
LPI2C
EnsemblGenome_TRS:
YPL146C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPL146C
RefSeq:
NP_015179.1
|
| Others |
UniRef100:
UniRef100_Q12080
UniRef90:
UniRef90_Q12080
UniRef50:
UniRef50_Q12080
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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