| Type | Description |
|---|---|
| Definition | serine/threonine/tyrosine protein kinase RAD53 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:35:00 | Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53. | 32701054 |
| 2020-09-19 16:28:00 | The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing. | 32814778 |
| 2020-05-23 10:53:00 | We show here that Exo1 phosphorylation is Dun1-independent and Rad53-dependent in response to DNA damage or dNTP depletion, and in both situations Exo1 is similarly phosphorylated at multiple sites. | 32020204 |
| 2020-02-22 10:37:00 | Here we show that Rad53 drives the hyper-SUMOylation of Pol2, the catalytic subunit of DNA polymerase epsilon, principally following replication forks stalling induced by nucleotide depletion | 31765407 |
| 2019-06-01 12:48:00 | Rad53 binds to forkhead-associated (FHA) interaction motifs in an unstructured loop region of Cdc45, which is phosphorylated by Rad53 itself, and this interaction is necessary for the inhibition of origin firing through Sld3. Cdc45 also recruits Rad53 to stalled replication forks, which we demonstrate is important for the response to replication stress. | 30595439 |
| Type | IDs |
|---|---|
| Synonymous | LSD1, MEC2, SPK1 |
| Gene |
UniProtKB-ID:
RAD53_YEAST
UniprotKB:
P22216
UniParc:
UPI000005328E
EMBL:
BK006949,
AY693009,
M55623,
Z73509,
X96770
EnsemblGenome:
YPL153C
KO:
sce:YPL153C
|
| Nucleutide sequences |
EMBL-CDS:
DAA11281.1,
CAA65568.1,
AAA35070.1,
AAT93028.1,
CAA97858.1
Gene_ORFName:
P2588
EnsemblGenome_TRS:
YPL153C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YPL153C
RefSeq:
NP_015172.1
|
| Others |
UniRef100:
UniRef100_P22216
UniRef90:
UniRef90_P22216
UniRef50:
UniRef50_P22216
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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