| Type | Description |
|---|---|
| Definition | DNA topoisomerase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:38:00 | Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae. | 32152049 |
| 2020-12-19 13:44:00 | Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast. | 33046655 |
| 2020-02-29 12:15:00 | Data highlights the role of Uls1 in antagonizing Top2 function. Remodelling Top2 binding is thus an important new means by which Snf2 enzymes promote genome stability. | 31106359 |
| 2020-02-01 13:16:00 | Reaction rates for individual steps in the DNA cleavage reaction are characterized. Kinetic pathway of divalent ions in the DNA cleavage reaction is revealed. Sequence-preferential DNA bending is induced for the cleavage site selection by TOP2. | 30713098 |
| 2020-01-25 13:16:00 | We show that KDM4B modulates TOP2 accessibility to chromatin, elucidating a mechanism of TOP2 inhibitor sensitivity. These findings indicate that CRGs mediate anthracycline benefit by altering DNA accessibility, with implications for the stratification of patients with breast cancer and treatment decision making | 31700186 |
| Type | IDs |
|---|---|
| Synonymous | TOR3, TRF3 |
| Gene |
UniProtKB-ID:
TOP2_YEAST
UniprotKB:
P06786
UniParc:
UPI00000010F4
EMBL:
M13814,
AF458972,
Z71364,
AF458971,
BK006947,
AF458969,
X89016
EnsemblGenome:
YNL088W
KO:
sce:YNL088W
|
| Nucleutide sequences |
EMBL-CDS:
CAA95964.1,
AAM00536.1,
AAM00530.1,
AAB36610.1,
AAM00518.1,
CAA61422.1,
DAA10457.1
Gene_ORFName:
N2244
EnsemblGenome_TRS:
YNL088W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YNL088W
RefSeq:
NP_014311.3
|
| Others |
UniRef100:
UniRef100_P06786
UniRef90:
UniRef90_P06786
UniRef50:
UniRef50_P06786
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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