| Type | Description |
|---|---|
| Definition | MRX complex DNA-binding subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-02-02 13:29:00 | A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization. | 33278361 |
| 2021-01-02 12:51:00 | Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae. | 31769492 |
| 2019-10-12 12:38:00 | Here we describe two separation-of-functions alleles, mre11-S499P and rad50-A78T, which we show to specifically affect Tel1 activation without impairing MRX functions in DSB repair. Both Mre11-S499P and Rad50-A78T reduce Tel1-MRX interaction leading to poor Tel1 association at DSBs and consequent loss of Tel1 activation | 30698745 |
| 2019-07-27 12:23:00 | Data show that ssDNA endodeoxyribonuclease SAE2 (Sae2) cooperates with the Mre11-Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. | 29420790 |
| 2019-01-12 11:00:00 | Phosphorylation of ssDNA endodeoxyribonuclease SAE2 (Sae2)does not affect its overall capacity to interact with Mre11-Rad50-Xrs2 (MRX), it controls the specific physical and functional interaction with the MRX subunit Rad50, which is a prerequisite for the regulation of the Mre11 nuclease. | 30275497 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RAD50_YEAST
UniprotKB:
P12753
UniParc:
UPI000004C4DD
EMBL:
Z71526,
BK006947,
X14814,
X96722
EnsemblGenome:
YNL250W
KO:
sce:YNL250W
|
| Nucleutide sequences |
EMBL-CDS:
CAA65494.1,
DAA10309.1,
CAA96157.1,
CAA32919.1
Gene_ORFName:
N0872
EnsemblGenome_TRS:
YNL250W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YNL250W
RefSeq:
NP_014149.1
|
| Others |
UniRef100:
UniRef100_P12753
UniRef90:
UniRef90_P12753
UniRef50:
UniRef50_P12753
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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