| Type | Description |
|---|---|
| Definition | DNA polymerase epsilon catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:37:00 | Study show that, in Saccharomyces cerevisiae, the mutation rate increases synergistically when a Polepsilon nucleotide selectivity defect is combined with a Poldelta proofreading defect, demonstrating extrinsic proofreading of Polepsilon errors by Poldelta. Combining Poldelta nucleotide selectivity and Polepsilon proofreading defects produces no synergy, indicating that Polepsilon cannot correct errors made by Poldelta. | 32123096 |
| 2020-02-22 10:37:00 | Our findings thus indicate a direct role for SUMO in Pol2-mediated DNA synthesis and a molecular basis for Smc5/6-mediated regulation of genome stability | 31765372 |
| 2020-02-22 10:37:00 | Here we show that Rad53 drives the hyper-SUMOylation of Pol2, the catalytic subunit of DNA polymerase epsilon, principally following replication forks stalling induced by nucleotide depletion | 31765407 |
| 2018-12-01 12:17:00 | DNA polymerase epsilon outcompetes double-stranded DNA for recruiting Ctf18-RFC to the replisome. | 29225079 |
| 2017-05-13 20:46:00 | To dissect the Saccharomyces cerevisiae RNA polymerase II TL at individual-residue resolution, we quantitatively phenotyped nearly all TL single variants en masse.Our structural genetics approach incorporates structural and phenotypic data for high-resolution dissection of transcription mechanisms and their evolution, and is readily applicable to other essential yeast proteins. | 27898685 |
| Type | IDs |
|---|---|
| Synonymous | DUN2 |
| Gene |
UniProtKB-ID:
DPOE_YEAST
UniprotKB:
P21951
UniParc:
UPI00001297C9
EMBL:
BK006947,
M60416,
X92494,
Z71538
EnsemblGenome:
YNL262W
KO:
sce:YNL262W
|
| Nucleutide sequences |
EMBL-CDS:
AAA88711.1,
CAA96169.1,
DAA10297.1,
CAA63235.1
Gene_ORFName:
N0825
EnsemblGenome_TRS:
YNL262W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YNL262W
RefSeq:
NP_014137.1
|
| Others |
UniRef100:
UniRef100_P21951
UniRef90:
UniRef90_P21951
UniRef50:
UniRef50_P21951
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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