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855264 MRE11

855264

MRE11

MRX complex nuclease subunit

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition MRX complex nuclease subunit

研究结论

Date Results Publications
2021-02-02 13:29:00 A Role for the Mre11-Rad50-Xrs2 Complex in Gene Expression and Chromosome Organization. 33278361
2021-01-02 12:51:00 Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae. 31769492
2019-10-12 12:38:00 Here we describe two separation-of-functions alleles, mre11-S499P and rad50-A78T, which we show to specifically affect Tel1 activation without impairing MRX functions in DSB repair. Both Mre11-S499P and Rad50-A78T reduce Tel1-MRX interaction leading to poor Tel1 association at DSBs and consequent loss of Tel1 activation 30698745
2019-07-27 12:23:00 Data show that ssDNA endodeoxyribonuclease SAE2 (Sae2) cooperates with the Mre11-Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. 29420790
2019-07-06 10:05:00 A harmless head-on replication-transcription clash resolution requires the fine-tuning of origin firing and coordination among Sen1, Exo1, Mre11 and Mrc1-Ctf4 complexes. 29059325

名称对应

Type IDs
Synonymous NGS1, RAD58, XRS4
Gene
UniProtKB-ID: MRE11_YEAST
UniprotKB: P32829
UniParc: UPI000004C4DA
EMBL: U60829, D11463, Z49939, BK006946
EnsemblGenome: YMR224C
KO: sce:YMR224C
Nucleutide sequences
EMBL-CDS: BAA02017.1, DAA10123.1, CAA90195.1, AAB61454.1
Gene_ORFName: YM9959.06C
EnsemblGenome_TRS: YMR224C_mRNA
Protein sequencees
EnsemblGenome_PRO: YMR224C
RefSeq: NP_013951.1
Others
UniRef100: UniRef100_P32829
UniRef90: UniRef90_P32829
UniRef50: UniRef50_P32829

全选

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