| Type | Description |
|---|---|
| Definition | ubiquitin-specific protease UBP8 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-08 10:40:00 | We show here that mutating the active site cysteine of human USP4 and yeast Ubp8 to alanine increases the affinity of the DUB for mono- or diubiquitin by 10-150-fold. | 30150323 |
| 2012-12-29 11:40:00 | an unexpected role for Sgf11 in compensating for the absence of structural features that maintain the active conformation of Ubp8. | 22771212 |
| 2011-09-17 11:27:00 | Ubp8 can deubiquitinate Snf1, a highly conserved AMP-activated serine/threonine protein kinase that serves as an energy sensor in the cell. | 21628526 |
| 2010-06-14 11:18:00 | study reports the 1.90 angstrom resolution crystal structure of the deubiquitinating module (DUBm)- which contains Ubp8 bound to Sgf11, Sus1 and Sgf73- bound to ubiquitin aldehyde, as well as the 2.45 angstrom resolution structure of the uncomplexed DUBm | 20395473 |
| 2010-05-31 11:24:00 | Structural and functional analyses reveal a central role of Sgf11 and Sgf73 in activating Ubp8 for deubiquitinating histone H2B and demonstrate how a DUB can be allosterically regulated by its nonsubstrate partners. | 20434206 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
UBP8_YEAST
UniprotKB:
P50102
UniParc:
UPI0000053135
EMBL:
Z49939,
BK006946
EnsemblGenome:
YMR223W
KO:
sce:YMR223W
|
| Nucleutide sequences |
EMBL-CDS:
DAA10122.1,
CAA90194.1
Gene_ORFName:
YM9959.05
EnsemblGenome_TRS:
YMR223W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YMR223W
RefSeq:
NP_013950.1
|
| Others |
UniRef100:
UniRef100_P50102
UniRef90:
UniRef90_P50102
UniRef50:
UniRef50_P50102
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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