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855143 ASC1

855143

ASC1

guanine nucleotide-binding protein subunit beta

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition guanine nucleotide-binding protein subunit beta

研究结论

Date Results Publications
2019-04-13 11:29:00 Mbf1 and Rps3 cooperate to maintain the reading frame of stalled ribosomes, while Asc1 also mediates distinct events that result in recruitment of the ribosome quality control complex and mRNA decay. 30465652
2018-07-21 11:15:00 Data provide evidence that Asc1 seems to connect signal transduction not only with the translational machinery, but also with fundamental nuclear processes. 28982715
2018-05-05 12:06:00 These indicate that ribosome-associated Asc1/RACK1 facilitates endonucleolytic cleavage of nonstop mRNA by stalled ribosomes and represses the levels of aberrant products even in the absence of Dom34. We propose that Asc1/RACK1 acts as a fail-safe in quality control for nonstop mRNA. 27312062
2017-12-09 12:30:00 identify Asc1p (aka RACK1) and Rps3p, both stable 40S subunit components, as additional 18S nonfunctional 18S rRNA decay factors 28956756
2017-06-10 10:19:00 premature arrest at ribosome stalling sequences still occurred robustly in the absence of Asc1, Hel2, and Slh1. However, these three factors were required for the ribosome quality control complex to modify the nascent chain. 28223409

名称对应

Type IDs
Synonymous ASU9, CPC2, NAD1
Gene
UniProtKB-ID: GBLP_YEAST
UniprotKB: P38011
UniParc: UPI0000052E47
EMBL: BK006946, Z49702
EnsemblGenome: YMR116C
KO: sce:YMR116C
Nucleutide sequences
EMBL-CDS: CAA89754.1, DAA10013.1, CAA89753.1
Gene_ORFName: YM9718.15C
EnsemblGenome_TRS: YMR116C_mRNA
Protein sequencees
EnsemblGenome_PRO: YMR116C
RefSeq: NP_013834.1
Others
UniRef100: UniRef100_P38011
UniRef90: UniRef90_P38011
UniRef50: UniRef50_P38011

全选

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研究热度

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