| Type | Description |
|---|---|
| Definition | copper chaperone CCS1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-05 11:51:00 | Lack of SOD1 in a RAD51 mutant depending on CCS1 exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae. | 30223018 |
| 2019-05-18 11:34:00 | propose a complete molecular mechanism for CCS1 activity and reclassification as a first-of-its-kind "dual chaperone." | 30530491 |
| 2017-08-12 12:04:00 | Data suggest that Ccs1 activates immature Sod1 by delivering copper and facilitating oxidation of intramolecular disulfide bond in Sod1; Ccs1 binding exposes an electropositive cavity and proposed "entry site" for copper ion delivery on the apoenzyme. (Ccs1 = copper chaperone for superoxide dismutase; Sod1 = copper-zinc superoxide dismutase) | 28533431 |
| 2014-05-03 12:12:00 | Data show that the aging process increased the DNA damage rates 3-fold in the wild type and more than 5-fold in superoxide dismutases sod1Delta, sod2Delta, and molecular chaperone ccs1Delta mutant cells. | 24462872 |
| 2014-03-01 11:50:00 | CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. | 24297923 |
| Type | IDs |
|---|---|
| Synonymous | LYS7 |
| Gene |
UniProtKB-ID:
CCS1_YEAST
UniprotKB:
P40202
UniParc:
UPI0000111F87
EMBL:
Z48502,
U17378,
AY558398,
BK006946
EnsemblGenome:
YMR038C
KO:
sce:YMR038C
|
| Nucleutide sequences |
EMBL-CDS:
AAC49068.1,
CAA88404.1,
DAA09937.1,
AAS56724.1
Gene_ORFName:
YM9532.03C
EnsemblGenome_TRS:
YMR038C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YMR038C
RefSeq:
NP_013752.1
|
| Others |
UniRef100:
UniRef100_P40202
UniRef90:
UniRef90_P40202
UniRef50:
UniRef50_P40202
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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