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854980 TSA1

854980

TSA1

thioredoxin peroxidase TSA1

protein-coding

Saccharomyces cerevisiae S288c

基因描述

Type Description
Definition thioredoxin peroxidase TSA1

研究结论

Date Results Publications
2021-02-20 13:34:00 Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A. 32662770
2020-09-05 13:53:00 Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast. 31580947
2020-02-15 10:31:00 It findings indicate that multiple steps in the catalytic cycle of Tsa1 may be impaired by introducing substitutions at its decamer-building interface, suggesting a multifaceted biological basis for its assembly into decamers. 30701970
2017-01-14 11:56:00 Study found that Tsa1 and Hsp70 physically interact and that hyperoxidation of Tsa1 by hydrogen peroxide is required for the recruitment of the Hsp70 chaperones and the Hsp104 disaggregase to misfolded and aggregated proteins during aging, but not heat stress. 27264606
2016-09-03 12:05:00 The critical molecular event allowing the Tsa1 to chaperone switch is the enzyme assembly into high molecular weight structures brought about by enzyme hyperoxidation and sulfinylation. 26335398

名称对应

Type IDs
Synonymous TPX1, ZRG14
Gene
UniProtKB-ID: TSA1_YEAST
UniprotKB: P34760
UniParc: UPI000002FC87
EMBL: BK006946, Z46659, L14640
EnsemblGenome: YML028W
KO: sce:YML028W
Nucleutide sequences
EMBL-CDS: CAA86627.1, DAA09870.1, AAA16374.1
EnsemblGenome_TRS: YML028W_mRNA
Protein sequencees
EnsemblGenome_PRO: YML028W
RefSeq: NP_013684.1
Others
UniRef100: UniRef100_P34760
UniRef90: UniRef90_P34760
UniRef50: UniRef50_P34760

全选

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研究热度

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