| Type | Description |
|---|---|
| Definition | MIND complex subunit DSN1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 11:20:00 | Csm1 binds two conserved motifs in Dsn1, one (termed Box 1) representing the ancestral, widely conserved monopolin binding motif and a second (termed Box 2-3) with a likely role in enforcing specificity of sister kinetochore crosslinking. We find that Box 1 and Box 2-3 bind the same conserved hydrophobic cavity on Csm1, suggesting competition or handoff between these motifs. More information in the paper. | 31037469 |
| 2019-02-02 10:10:00 | We used this assay to investigate why kinetochores recruit the microtubule-binding Ndc80 complex via two receptors: the Mis12 complex and CENP-T. Although the CENP-T pathway is non-essential in yeast, we demonstrate that it becomes essential for viability and Ndc80c recruitment when the Mis12 pathway is crippled by defects in Dsn1 phosphorylation | 30117803 |
| 2018-07-21 11:31:00 | Altogether, these data indicate that the absence of R37 methylation on Cse4 reduces the recruitment of kinetochore proteins to centromeric chromatin, and that this can be compensated for by stabilizing the outer kinetochore protein Dsn1 via the ubiquitin ligase complex Ubr2/Mub1. | 28158539 |
| 2014-02-15 10:02:00 | We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast. | 23636741 |
| 2013-06-15 12:05:00 | Consistent with this, Mub1/Ubr2 help to maintain viability when kinetochores are defective. Together, our data identify a previously unknown regulatory mechanism for the conserved Dsn1 kinetochore protein | 23408894 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DSN1_YEAST
UniprotKB:
P40568
UniParc:
UPI000013B47C
EMBL:
BK006942,
X79743,
Z37996
EnsemblGenome:
YIR010W
KO:
sce:YIR010W
|
| Nucleutide sequences |
EMBL-CDS:
DAA08556.1,
CAA86080.1
Gene_ORFName:
YIB10W
EnsemblGenome_TRS:
YIR010W_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YIR010W
RefSeq:
NP_012275.3
|
| Others |
UniRef100:
UniRef100_P40568
UniRef90:
UniRef90_P40568
UniRef50:
UniRef50_P40568
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
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