| Type | Description |
|---|---|
| Definition | 3'-5' DNA helicase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 16:01:00 | Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres. | 33264397 |
| 2020-05-16 10:38:00 | Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability | 31569000 |
| 2019-11-30 11:36:00 | Through molecular genetic analysis of this defined fork-stalling event, coupled with the use of a genome-wide genetic screen, we identified an important role for the SUMO-like domain protein, Esc2, in limiting genome rearrangements at a telomere. Moreover, we showed that these rearrangements are driven by the combined action of the Mph1 helicase and the homologous recombination machinery | 30838410 |
| 2018-03-03 11:07:00 | Mph1 is a double-edged sword whose action at hybrids must be regulated by the Smc5/6 complex. This is underlined by the observation that simultaneous inactivation of RNase H2 and Smc5/6 results in Mph1-dependent synthetic lethality. | 29281624 |
| 2017-05-27 10:07:00 | mms21RINGDelta mutant exhibits (1) reduced ribosomal RNA production; (2) nuclear accumulation of ribosomal proteins; (3) elevated Gcn4 translation, indicating translational stress; We identified RPL19A as a novel genetic suppressor of the mms21RINGDelta mutant; Deletion of a previously identified strong suppressor, MPH1, rescues both the accumulation of ribosome subunits and translational stress | 27510371 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
MPH1_YEAST
UniprotKB:
P40562
UniParc:
UPI000005304E
EMBL:
Z38062,
X79743,
BK006942
EnsemblGenome:
YIR002C
KO:
sce:YIR002C
|
| Nucleutide sequences |
EMBL-CDS:
CAA86204.1,
DAA08548.1
Gene_ORFName:
YIB2C
EnsemblGenome_TRS:
YIR002C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YIR002C
RefSeq:
NP_012267.1
|
| Others |
UniRef100:
UniRef100_P40562
UniRef90:
UniRef90_P40562
UniRef50:
UniRef50_P40562
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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