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85464 SSH2

85464

SSH2

slingshot protein phosphatase 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition slingshot protein phosphatase 2

研究结论

Date Results Publications
2019-03-23 11:13:00 the N-terminal region of human Slingshot2 auto-inhibits its phosphatase activity in a noncompetitive manner 30154244
2015-10-31 10:53:00 Novel signaling pathway consisting of chemoattractant GPCR/Galphai protein, PLC, and PKDs that regulates SSH2/cofilin activity, F-actin polymerization and directional assembly of actin cytoskeleton in neutrophil chemotaxis was identified. 25568344
2014-04-26 12:26:00 data indicate that: (a) apoptotic cell death in FLCN-null cells can be triggered by SSH2 knockdown through cell cycle arrest; (b) SSH2 represents a potential therapeutic target for the development of agents for the treatment of BHD syndrome related tumors 23416984
2010-06-30 22:05:00 Observational study of gene-disease association. (HuGE Navigator) 20477815
2010-01-21 00:00:00 Expression of phosphatase-dead versions of SSH proteins, SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes. 17848544

名称对应

Type IDs
Synonymous SSH-2, SSH-2L
Gene
UniProtKB-ID: SSH2_HUMAN, B4DK64_HUMAN, A0A3B3ITS1_HUMAN, F5H527_HUMAN
UniprotKB: Q76I76, B4DK64, A0A3B3ITS1, F5H527
UniParc: UPI00005E2744, UPI00005E2743, UPI0002065A97, UPI000006EACD, UPI00017A71EA, UPI000006EAE3, UPI00001D6272
EMBL: AC104564, AC104982, BC011636, AK296413, AF484838, AB051512, AB099290, AB072359, BC008941, BC068223, CH471159, AB072358, AC023389, AC087510
Ensembl: ENSG00000141298
KO: hsa:85464
Nucleutide sequences
EMBL-CDS: AAH11636.2, BAC97813.1, AAL92027.1, BAB84118.1, AAH68223.1, BAB21816.1, AAH08941.1, BAB84117.1, BAG59076.1, EAW51209.1
Gene_ORFName: hCG_2003225
Ensembl_TRS: ENST00000269033, ENST00000324677, ENST00000540801
Protein sequencees
Ensembl_PRO: ENSP00000269033, ENSP00000497894, ENSP00000444743
RefSeq: XP_005258115.1, NP_203747.2, XP_016880741.1, NP_001269058.1, XP_011523704.1, XP_005258117.1, XP_016880744.1, XP_011523709.1, NP_001269059.1, XP_005258116.1, XP_016880742.1, XP_016880740.1, XP_016880743.1, XP_011523707.1, NP_001269060.1, XP_011523706.1, XP_006722212.1, XP_011523708.1
Others
UniRef100: UniRef100_A0A3B3ITS1, UniRef100_B4DK64, UniRef100_Q76I76, UniRef100_F5H527
UniRef90: UniRef90_Q76I76, UniRef90_Q76I76-2
UniRef50: UniRef50_Q76I76, UniRef50_Q76I76-2
UniGene: Hs.654754
CCDS: CCDS11253.1

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