| Type | Description |
|---|---|
| Definition | serine/threonine protein kinase MEK1 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-02 12:08:00 | Using genetic and biochemical approaches, this work demonstrates that in the presence of DSBs, activated Mek1 binds to Ndt80 and phosphorylates the transcription factor, thus inhibiting DNA binding and preventing Ndt80's function as a transcriptional activator. | 30496175 |
| 2019-01-19 10:09:00 | crystal structures of the Mek1 FHA domain in the apo state and in complex with the Hop1 pT318 peptide are presented, demonstrating that the hydrophobic residues Phe320 and Val321 at the pT+2 and pT+3 positions in the ligand contribute to the preferential recognition. | 30289413 |
| 2018-07-21 11:50:00 | These localization patterns closely tracked the distribution of Red1 and Hop1, axis proteins required for Mek1 activation. These findings provide insight into the spatial disposition of Mek1 kinase activity and the higher order organization of recombining meiotic chromosomes | 28986445 |
| 2017-07-15 10:17:00 | ndt80 transcription of CDC5 results in degradation of Red1, a meiosis-specific protein required for Mek1 activation, thereby abolishing Mek1 activity completely. Elimination of Mek1 kinase activity allows Rad51-mediated repair of any remaining DSBs. In this way, cells do not enter Meiosis I until recombination is complete and all DSBs are repair | 28249986 |
| 2017-05-27 10:20:00 | ad51-mediated recombination occurring in the absence of Hed1 phosphorylation results in a significant increase in non-exchange chromosomes despite wild-type levels of crossovers, confirming previous results indicating a defect in crossover assurance. We propose that Rad51 function in meiosis is regulated in part by the coordinated phosphorylation of Rad54 and Hed1 by Mek1 | 27483004 |
| Type | IDs |
|---|---|
| Synonymous | MRE4 |
| Gene |
UniProtKB-ID:
MEK1_YEAST
UniprotKB:
P24719
UniParc:
UPI000012EEC5
EMBL:
BK006948,
Z75259,
X61208,
X63112,
X95720
EnsemblGenome:
YOR351C
KO:
sce:YOR351C
|
| Nucleutide sequences |
EMBL-CDS:
CAA65038.1,
CAA44825.1,
CAA43522.1,
DAA11112.1,
CAA99680.1
Gene_ORFName:
O6357
EnsemblGenome_TRS:
YOR351C_mRNA
|
| Protein sequencees |
EnsemblGenome_PRO:
YOR351C
RefSeq:
NP_014996.3
|
| Others |
UniRef100:
UniRef100_P24719
UniRef90:
UniRef90_P24719
UniRef50:
UniRef50_P24719
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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